RALPH DE OLIVEIRA, Isabella Luiza; DA SILVA MOURA, José Arion; RECORDON-PINSON, Patricia; LAGADEC, Floriane; DA ROSA, Michelle Melgarejo; GONÇALVES, Sayonara Maria Calado; VIANA, Douglas Carvalho Francisco; DE MORAES GOMES, Paulo André Teixeira; DA ROCHA PITTA, Marina Galdino; DE MELO RÊGO, Moacyr Jesus Barreto; PEREIRA, Michelly Cristiny; MÉTIFIOT, Mathieu; ANDREOLA, Marie-Line; DA ROCHA PITTA, Maira Galdino

doi:10.3390/microorganisms13091967

RECORDON-PINSON, Patricia
Microbiologie Fondamentale et Pathogénicité [MFP]

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Microorganisms. 2025-08-22, vol. 13, n° 9

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Zika virus (ZIKV) remains a pressing global health concern due to its association with congenital Zika syndrome and the current lack of approved antiviral therapies. In this study, we evaluated the antiviral activity of three novel thiazolidinedione derivatives, GQ-402, GQ-396, and ZKC-10, against ZIKV in vitro and investigated their potential molecular targets through in silico analysis. GQ-402 exhibited the highest antiviral potency, with an IC of 15.7 µM, while ZKC-10 achieved the most substantial reduction in viral RNA levels, as determined by RT-qPCR. Molecular docking studies identified GQ-396 as the top-ranked inhibitor of the NS2B-NS3 protease and NS5 RNA-dependent RNA polymerase, suggesting distinct mechanisms of action among the compounds. These findings highlight the therapeutic potential of thiazolidinedione derivatives and underscore the need for further investigation to develop effective treatments for ZIKV infection.< Leer menos

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https://oskar-bordeaux.fr/handle/20.500.12278/207680

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http://dx.doi.org/10.3390/microorganisms13091967

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MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234

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Novel Thiazolidinedione Derivatives as Potential ZIKV Antiviral Inhibitors.

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