Novel Thiazolidinedione Derivatives as Potential ZIKV Antiviral Inhibitors.
| dc.rights.license | open | en_US |
| dc.contributor.author | RALPH DE OLIVEIRA, Isabella Luiza | |
| dc.contributor.author | DA SILVA MOURA, José Arion | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | RECORDON-PINSON, Patricia | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | LAGADEC, Floriane | |
| dc.contributor.author | DA ROSA, Michelle Melgarejo | |
| dc.contributor.author | GONÇALVES, Sayonara Maria Calado | |
| dc.contributor.author | VIANA, Douglas Carvalho Francisco | |
| dc.contributor.author | DE MORAES GOMES, Paulo André Teixeira | |
| dc.contributor.author | DA ROCHA PITTA, Marina Galdino | |
| dc.contributor.author | DE MELO RÊGO, Moacyr Jesus Barreto | |
| dc.contributor.author | PEREIRA, Michelly Cristiny | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | MÉTIFIOT, Mathieu | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | ANDREOLA, Marie-Line | |
| dc.contributor.author | DA ROCHA PITTA, Maira Galdino | |
| dc.date.accessioned | 2025-09-29T10:45:22Z | |
| dc.date.available | 2025-09-29T10:45:22Z | |
| dc.date.issued | 2025-08-22 | |
| dc.identifier.issn | 2076-2607 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/207680 | |
| dc.description.abstractEn | Zika virus (ZIKV) remains a pressing global health concern due to its association with congenital Zika syndrome and the current lack of approved antiviral therapies. In this study, we evaluated the antiviral activity of three novel thiazolidinedione derivatives, GQ-402, GQ-396, and ZKC-10, against ZIKV in vitro and investigated their potential molecular targets through in silico analysis. GQ-402 exhibited the highest antiviral potency, with an IC of 15.7 µM, while ZKC-10 achieved the most substantial reduction in viral RNA levels, as determined by RT-qPCR. Molecular docking studies identified GQ-396 as the top-ranked inhibitor of the NS2B-NS3 protease and NS5 RNA-dependent RNA polymerase, suggesting distinct mechanisms of action among the compounds. These findings highlight the therapeutic potential of thiazolidinedione derivatives and underscore the need for further investigation to develop effective treatments for ZIKV infection. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.title.en | Novel Thiazolidinedione Derivatives as Potential ZIKV Antiviral Inhibitors. | |
| dc.title.alternative | Microorganisms | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/microorganisms13091967 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Microbiologie et Parasitologie | en_US |
| dc.identifier.pubmed | 41011300 | en_US |
| bordeaux.journal | Microorganisms | en_US |
| bordeaux.volume | 13 | en_US |
| bordeaux.hal.laboratories | MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234 | en_US |
| bordeaux.issue | 9 | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-05288475 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-09-29T10:45:26Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Microorganisms&rft.date=2025-08-22&rft.volume=13&rft.issue=9&rft.eissn=2076-2607&rft.issn=2076-2607&rft.au=RALPH%20DE%20OLIVEIRA,%20Isabella%20Luiza&DA%20SILVA%20MOURA,%20Jos%C3%A9%20Arion&RECORDON-PINSON,%20Patricia&LAGADEC,%20Floriane&DA%20ROSA,%20Michelle%20Mel&rft.genre=article |