HOMOBONO BRITO DE MOURA, Patricia; LELEU, Guillaume; DA COSTA, Grégory; MARTI, Guillaume; PÉTRIACQ, Pierre; VALLS FONAYET, Josep; RICHARD, Tristan

doi:10.3390/molecules30122624

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HOMOBONO BRITO DE MOURA, Patricia
Unité de Recherche Œnologie [Villenave d'Ornon] [OENO]
Biologie du fruit et pathologie [BFP]

LELEU, Guillaume
Unité de Recherche Œnologie [Villenave d'Ornon] [OENO]

DA COSTA, Grégory
Unité de Recherche Œnologie [Villenave d'Ornon] [OENO]
MetaboHUB-Bordeaux

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Article de revue

Ce document a été publié dans

Molecules. 2025-06-17, vol. 30, n° 12, p. 2624

MDPI

Résumé en anglais

Metabolomics, the comprehensive analysis of low-molecular-weight metabolites (typically below 1500 DA) in biological systems, relies heavily on mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. Each technique has inherent strengths and weaknesses. MS offers high sensitivity and is commonly coupled with chromatography to analyze complex matrices, yet it is destructive, has limited reproducibility, and provides limited structural information. NMR, while less sensitive, is non-destructive and enables structural elucidation and precise quantification. Recent studies increasingly employ data fusion (DF) strategies to combine the complementary information from NMR and MS, aiming to enhance metabolomic analyses. This review summarizes DF methodologies using NMR and MS data in metabolomics studies over the past decade. A comprehensive search of SciFinder, Scopus, and Clarivate Web of Science databases was conducted to analyze fusion techniques, methods, and statistical models. The review emphasizes the growing importance of DF in metabolomics, showing its capacity to provide a more comprehensive view of biochemical processes across diverse biological systems, including clinical, plant, and food matrices.< Réduire

Mots clés en anglais

metabolomics

data fusion

nuclear magnetic resonance (NMR)

mass spectrometry (MS)

multi-omics

URI

https://oskar-bordeaux.fr/handle/20.500.12278/207384

DOI

http://dx.doi.org/10.3390/molecules30122624

Project ANR

Développement d'une infrastructure française distribuée pour la métabolomique dédiée à l'innovation - ANR-11-INBS-0010
Projet vin authenticité en RMN - ANR-21-CE21-0014

Origine

Importé de hal

Unités de recherche

Biologie du Fruit & Pathologie (BFP) - UMR 1332