Afficher la notice abrégée

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorNICOLAS, Jean Charles
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLEE, Thomas H.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorQUARTA, Carmelo
dc.date.accessioned2025-06-10T16:05:14Z
dc.date.available2025-06-10T16:05:14Z
dc.date.issued2024-12-05
dc.identifier.issn1043-2760en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/206863
dc.description.abstractEnIt has long been thought that the functional identity of mammalian brain neurons is programmed during development and remains stable throughout adult life; how-ever, certain populations of neurons continue to express active regulators of neu-ronal identity into adulthood. Prolonged exposure to diet-induced metabolic stress induces features of neuronal identity modification in adult mice, and mal-adaptive changes in neuronal identity maintenance have been linked to cognitive impairment in humans suffering from neurodegenerative diseases often associ-ated with obesity. Here we discuss how, by unraveling the neurological roots of obesity, we may solve the puzzle of whether mammalian brain neurons retain identity plasticity into adulthood, while advancing knowledge of the pathogenic mechanisms at the interface of metabolic and neurodegenerative disorders.
dc.description.sponsorshipRôle de Tbx3 dans la détermination de l'identité fonctionnelle des neurones POMC dans l'obésité - ANR-20-CE14-0046en_US
dc.description.sponsorshipIdentification des mécanismes de reprogrammation du destin neuroendocrinien en réponse à l'obésité maternelle - ANR-24-CE16-5198en_US
dc.description.sponsorshipUniversity of Bordeaux Neurocampus Graduate School - ANR-17-EURE-0028en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCell heterogeneity
dc.subject.enNeurodegeneration
dc.subject.enNeuronal identity
dc.subject.enObesity
dc.title.enCan brain neurons change identity? Lessons from obesity
dc.title.alternativeTrends Endocrinol Metaben_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.tem.2024.11.006en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed39643545en_US
dc.description.sponsorshipEuropeEuropean Research councilen_US
dc.description.sponsorshipEuropeProgram Initiative d’Excellenceen_US
bordeaux.journalTrends in Endocrinology and Metabolismen_US
bordeaux.hal.laboratoriesNeurocentre Magendie - U1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamPhysiopathologie de l'équilibre énergétique et obésitéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-05106210
hal.version1
hal.date.transferred2025-06-10T16:05:17Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Trends%20in%20Endocrinology%20and%20Metabolism&rft.date=2024-12-05&rft.eissn=1043-2760&rft.issn=1043-2760&rft.au=NICOLAS,%20Jean%20Charles&LEE,%20Thomas%20H.&QUARTA,%20Carmelo&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Thumbnail

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée