Can brain neurons change identity? Lessons from obesity
dc.rights.license | open | en_US |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | NICOLAS, Jean Charles | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | LEE, Thomas H. | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | QUARTA, Carmelo | |
dc.date.accessioned | 2025-06-10T16:05:14Z | |
dc.date.available | 2025-06-10T16:05:14Z | |
dc.date.issued | 2024-12-05 | |
dc.identifier.issn | 1043-2760 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206863 | |
dc.description.abstractEn | It has long been thought that the functional identity of mammalian brain neurons is programmed during development and remains stable throughout adult life; how-ever, certain populations of neurons continue to express active regulators of neu-ronal identity into adulthood. Prolonged exposure to diet-induced metabolic stress induces features of neuronal identity modification in adult mice, and mal-adaptive changes in neuronal identity maintenance have been linked to cognitive impairment in humans suffering from neurodegenerative diseases often associ-ated with obesity. Here we discuss how, by unraveling the neurological roots of obesity, we may solve the puzzle of whether mammalian brain neurons retain identity plasticity into adulthood, while advancing knowledge of the pathogenic mechanisms at the interface of metabolic and neurodegenerative disorders. | |
dc.description.sponsorship | Rôle de Tbx3 dans la détermination de l'identité fonctionnelle des neurones POMC dans l'obésité - ANR-20-CE14-0046 | en_US |
dc.description.sponsorship | Identification des mécanismes de reprogrammation du destin neuroendocrinien en réponse à l'obésité maternelle - ANR-24-CE16-5198 | en_US |
dc.description.sponsorship | University of Bordeaux Neurocampus Graduate School - ANR-17-EURE-0028 | en_US |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject.en | Cell heterogeneity | |
dc.subject.en | Neurodegeneration | |
dc.subject.en | Neuronal identity | |
dc.subject.en | Obesity | |
dc.title.en | Can brain neurons change identity? Lessons from obesity | |
dc.title.alternative | Trends Endocrinol Metab | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1016/j.tem.2024.11.006 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
dc.identifier.pubmed | 39643545 | en_US |
dc.description.sponsorshipEurope | European Research council | en_US |
dc.description.sponsorshipEurope | Program Initiative d’Excellence | en_US |
bordeaux.journal | Trends in Endocrinology and Metabolism | en_US |
bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | Physiopathologie de l'équilibre énergétique et obésité | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-05106210 | |
hal.version | 1 | |
hal.date.transferred | 2025-06-10T16:05:17Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
dc.rights.cc | CC BY | en_US |
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