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Can brain neurons change identity? Lessons from obesity
NICOLAS, Jean Charles
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
LEE, Thomas H.
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
QUARTA, Carmelo
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
NICOLAS, Jean Charles
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
LEE, Thomas H.
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
QUARTA, Carmelo
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
< Reduce
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Language
EN
Article de revue
This item was published in
Trends in Endocrinology and Metabolism. 2024-12-05
English Abstract
It has long been thought that the functional identity of mammalian brain neurons is programmed during development and remains stable throughout adult life; how-ever, certain populations of neurons continue to express active ...Read more >
It has long been thought that the functional identity of mammalian brain neurons is programmed during development and remains stable throughout adult life; how-ever, certain populations of neurons continue to express active regulators of neu-ronal identity into adulthood. Prolonged exposure to diet-induced metabolic stress induces features of neuronal identity modification in adult mice, and mal-adaptive changes in neuronal identity maintenance have been linked to cognitive impairment in humans suffering from neurodegenerative diseases often associ-ated with obesity. Here we discuss how, by unraveling the neurological roots of obesity, we may solve the puzzle of whether mammalian brain neurons retain identity plasticity into adulthood, while advancing knowledge of the pathogenic mechanisms at the interface of metabolic and neurodegenerative disorders.Read less <
English Keywords
Cell heterogeneity
Neurodegeneration
Neuronal identity
Obesity
European Project
European Research council
Program Initiative d’Excellence
Program Initiative d’Excellence
ANR Project
Rôle de Tbx3 dans la détermination de l'identité fonctionnelle des neurones POMC dans l'obésité - ANR-20-CE14-0046
Identification des mécanismes de reprogrammation du destin neuroendocrinien en réponse à l'obésité maternelle - ANR-24-CE16-5198
University of Bordeaux Neurocampus Graduate School - ANR-17-EURE-0028
Identification des mécanismes de reprogrammation du destin neuroendocrinien en réponse à l'obésité maternelle - ANR-24-CE16-5198
University of Bordeaux Neurocampus Graduate School - ANR-17-EURE-0028
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