NICOLAS, Jean Charles; LEE, Thomas H.; QUARTA, Carmelo

doi:10.1016/j.tem.2024.11.006

NICOLAS, Jean Charles
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

LEE, Thomas H.
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

QUARTA, Carmelo
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Article de revue

Ce document a été publié dans

Trends in Endocrinology and Metabolism. 2024-12-05

Résumé en anglais

It has long been thought that the functional identity of mammalian brain neurons is programmed during development and remains stable throughout adult life; how-ever, certain populations of neurons continue to express active regulators of neu-ronal identity into adulthood. Prolonged exposure to diet-induced metabolic stress induces features of neuronal identity modification in adult mice, and mal-adaptive changes in neuronal identity maintenance have been linked to cognitive impairment in humans suffering from neurodegenerative diseases often associ-ated with obesity. Here we discuss how, by unraveling the neurological roots of obesity, we may solve the puzzle of whether mammalian brain neurons retain identity plasticity into adulthood, while advancing knowledge of the pathogenic mechanisms at the interface of metabolic and neurodegenerative disorders.< Réduire

Mots clés en anglais

Cell heterogeneity

Neurodegeneration

Neuronal identity

Obesity

URI

https://oskar-bordeaux.fr/handle/20.500.12278/206863

DOI

http://dx.doi.org/10.1016/j.tem.2024.11.006

Projet Européen

European Research council
Program Initiative d’Excellence

Project ANR

Rôle de Tbx3 dans la détermination de l'identité fonctionnelle des neurones POMC dans l'obésité - ANR-20-CE14-0046
Identification des mécanismes de reprogrammation du destin neuroendocrinien en réponse à l'obésité maternelle - ANR-24-CE16-5198
University of Bordeaux Neurocampus Graduate School - ANR-17-EURE-0028

Unités de recherche

Neurocentre Magendie - U1215

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Can brain neurons change identity? Lessons from obesity