| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | GÓMEZ-SOTRES, Paula | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | SKUPIO, Urszula | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | DALLA TOR, Tommaso | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | JULIO-KALAJZIC, Francisca | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | CANNICH, Astrid | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | GISQUET, Doriane | |
| dc.contributor.author | BONILLA-DEL RIO, Itziar | |
| dc.contributor.author | DRAGO, Filippo | |
| dc.contributor.author | PUENTE, Nagore | |
| dc.contributor.author | GRANDES, Pedro | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | BELLOCCHIO, Luigi | |
| dc.contributor.author | BUSQUETS-GARCIA, Arnau | |
| dc.contributor.author | BAINS, Jaideep S. | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | MARSICANO, Giovanni | |
| dc.date.accessioned | 2025-05-31T10:16:13Z | |
| dc.date.available | 2025-05-31T10:16:13Z | |
| dc.date.issued | 2024-08-18 | |
| dc.identifier.issn | 2041-1723 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/206803 | |
| dc.description.abstractEn | Emotions and behavior can be affected by social chemosignals from conspecifics. For instance, olfactory signals from stressed individuals induce stress-like physiological and synaptic changes in naïve partners. Direct stress also alters cognition, but the impact of socially transmitted stress on memory processes is currently unknown. Here we show that exposure to chemosignals produced by stressed individuals is sufficient to impair memory retrieval in unstressed male mice. This requires astrocyte control of information in the olfactory bulb mediated by mitochondria-associated CB1 receptors (mtCB1). Targeted genetic manipulations, in vivo Ca2+ imaging and behavioral analyses reveal that mtCB1-dependent control of mitochondrial Ca2+ dynamics is necessary to process olfactory information from stressed partners and to define their cognitive consequences. Thus, olfactory bulb astrocytes provide a link between social odors and their behavioral meaning. © The Author(s) 2024. | |
| dc.description.sponsorship | Développment d'une infrastructure française distribuée coordonnée | en_US |
| dc.description.sponsorship | Involvement of the insula in the Autism neurodevelopmental disorder | en_US |
| dc.description.sponsorship | Rôle du système endocannabinoïde de l'hippocampe dans le déficits de mémoire associés à l'obésité - ANR-23-CE14-0004 | en_US |
| dc.description.sponsorship | IdEx Bordeaux - ANR-10-IDEX-0003-02/10-IDEX-0003 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Astrocytes metabolism | |
| dc.subject.en | Behavior Animal physiology | |
| dc.subject.en | Calcium metabolism | |
| dc.subject.en | Cognition physiology | |
| dc.subject.en | Memory physiology | |
| dc.subject.en | Mice Inbred C57BL | |
| dc.subject.en | Mitochondria metabolism | |
| dc.subject.en | Odorants | |
| dc.subject.en | Olfactory Bulb metabolism | |
| dc.subject.en | Receptor | |
| dc.subject.en | Cannabinoid CB1 metabolism | |
| dc.subject.en | Smell physiology | |
| dc.subject.en | Social Behavior | |
| dc.subject.en | Stress Psychological | |
| dc.title.en | Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice | |
| dc.title.alternative | Nat Commun | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41467-024-51416-4 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 39155299 | en_US |
| dc.description.sponsorshipEurope | Mitochondrial Cannabinoid Receptors in the Brain | en_US |
| bordeaux.journal | Nature Communications | en_US |
| bordeaux.volume | 15 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - U1215 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | Endocannabinoïdes et Neuroadaptation | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.identifier.funderID | Instituto de Salud Carlos III | en_US |
| hal.identifier | hal-05091239 | |
| hal.version | 1 | |
| hal.date.transferred | 2025-05-31T10:16:22Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | CC BY-NC-ND | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2024-08-18&rft.volume=15&rft.issue=1&rft.eissn=2041-1723&rft.issn=2041-1723&rft.au=G%C3%93MEZ-SOTRES,%20Paula&SKUPIO,%20Urszula&DALLA%20TOR,%20Tommaso&JULIO-KALAJZIC,%20Francisca&CANNICH,%20Astrid&rft.genre=article | |
