BELLOCCHIO, Luigi; DIPALMA, Gianna; INCHINGOLO, Angelo Michele; INCHINGOLO, Alessio Danilo; FERRANTE, Laura; DEL VECCHIO, Gaetano; MALCANGI, Giuseppina; PALERMO, Andrea; QENDRO, Andis; INCHINGOLO, Francesco

doi:10.3390/biomedicines12010060

BELLOCCHIO, Luigi
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

DIPALMA, Gianna

INCHINGOLO, Angelo Michele

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Biomedicines. 2023-12-26, vol. 12, n° 1, p. 60

Résumé en anglais

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and transmission are generally known to be produced by respiratory droplets and aerosols from the oral cavity (O.C.) of infected subjects, as stated by the World Health Organization. Saliva also retains the viral particles and aids in the spread of COVID-19. Angiotensin-converting enzyme Type 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) are two of the numerous factors that promote SARS-CoV-2 infection, expressed by O.C. structures, various mucosa types, and the epithelia of salivary glands. A systemic SARS-CoV-2 infection might result from viral replication in O.C. cells. On the other hand, cellular damage of different subtypes in the O.C. might be associated with various clinical signs and symptoms. Factors interfering with SARS-CoV-2 infection potential might represent fertile ground for possible local pharmacotherapeutic interventions, which may confine SARS-CoV-2 virus entry and transmission in the O.C., finally representing a way to reduce COVID-19 incidence and severity. © 2023 by the authors.< Réduire

Mots clés en anglais

COVID-19

SARS-CoV-2

Infection

Oral cavity (O.C.)

Respiratory syndrome

Saliva transmission

Virus signs and symptoms

URI

https://oskar-bordeaux.fr/handle/20.500.12278/206688

DOI

http://dx.doi.org/10.3390/biomedicines12010060

Unités de recherche

Neurocentre Magendie - U1215

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COVID-19 on Oral Health: A New Bilateral Connection for the Pandemic

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Résumé en anglais

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