CUTUGNO, Giulia; KYRIAKIDOU, Evangelia; NADJAR, Agnes

doi:10.1016/j.neuropharm.2024.109951

CUTUGNO, Giulia
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

KYRIAKIDOU, Evangelia
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

NADJAR, Agnes

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Article de revue

Ce document a été publié dans

Neuropharmacology. 2024-08-01, vol. 253

Résumé en anglais

Microglia are the macrophages of the central nervous system (CNS), implying their role in maintaining brain homeostasis. To achieve this, these cells are sensitive to a plethora of endogenous and exogenous signals, such as neuronal activity, cellular debris, hormones, and pathological patterns, among many others. More recent research suggests that microglia are highly responsive to nutrients and dietary variations. In this context, numerous studies have demonstrated their significant role in the development of obesity under calorie surfeit. Because many reviews already exist on this topic, we have chosen to present the state of our reflections on various concepts put forth in the literature, bringing a new perspective whenever possible. Our literature review focuses on studies conducted in the arcuate nucleus of the hypothalamus, a key structure in the control of food intake. Specifically, we present the recent data available on the modifications of microglial energy metabolism following the consumption of an obesogenic diet and their consequences on hypothalamic neuron activity. We also highlight the studies unraveling the mechanisms underlying obesity-related sexual dimorphism. The review concludes with a list of questions that remain to be addressed in the field to achieve a comprehensive understanding of the role of microglia in the regulation of body energy metabolism. © 2024 The Authors< Réduire

Mots clés en anglais

Humans

Animals

Sex Difference

Animal

Pathology

Pathophysiology

Metabolism

Obesity

Physiology

Food Intake

Mammalian Target Of Rapamycin

Energy Metabolism

Metabolic Regulation

Obesogenic Diet

Hypothalamus

Neuromodulation

Energy Metabolism

Microglia

Arcuate Nucleus

Cell Interaction

Arcuate Nucleus Of Hypothalamus

Macrophage Function

Mtor Signaling

Nerve Function

Sex Characteristics

Sexual Characteristics

URI

https://oskar-bordeaux.fr/handle/20.500.12278/206650

DOI

http://dx.doi.org/10.1016/j.neuropharm.2024.109951

Project ANR

Rôle des altérations bioénergétiques microgliales précoces dans l'hétérogénéité des phénotypes obèses dépendante du sexe - ANR-23-CE14-0076

Unités de recherche

Neurocentre Magendie - U1215

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Rethinking the role of microglia in obesity