CHOULEUR, Tiffanie; ETCHEGARAY, Christele; VILLAIN, Laura; LESUR, Antoine; FERTE, Thomas; ROSSI, Marco; ANDRIQUE, Laetitia; SIMONCINI, Costanza; GIACOBBI, Anne-Sophie; GAMBARETTI, Matteo; LOPCI, Egesta; FERNADES, Bethania; DITTMAR, Gunnar; BJERKVIG, Rolf; HEJBLUM, Boris; THIEBAUT, Rodolphe; SAUT, Olivier; BELLO, Lorenzo; BIKFALVI, Andreas

doi:10.1002/ijc.35441

BoRdeaux Institute in onCology [Inserm U1312 - BRIC]

ETCHEGARAY, Christele

Institut de Mathématiques de Bordeaux [IMB]

VILLAIN, Laura

Statistics In System biology and Translational Medicine [SISTM]
Bordeaux population health [BPH]

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International Journal of Cancer. 2025-04-11

Résumé en anglais

Isocitrate dehydrogenase-mutant gliomas are lethal brain cancers that impair quality of life in young adults. Although less aggressive than glioblastomas, IDH-mutant gliomas invariably progress to incurable disease with unpredictable recurrence. A better classification of patient risk of recurrence is needed. Here, we describe a multimodal analytical pipeline integrating imaging, transcriptomic, and proteomic profiles using machine learning to improve patient stratification with novel signatures of patient risk of recurrence based on gene expression, protein level, and imaging. Additionally, we describe the biological characteristics of IDH-mutant glioma subtypes categorized by positron emission tomography (PET) and histology, and we reinforce the integration of positron emission tomography (PET) metrics in the classification of IDH-mutant gliomas. We identify a gene signature (KRT19, RUNX3, and SCRT2) and a protein signature (ATXN10, EIF4H, ITGAV, and NCAM1) associated with an increased risk of early recurrence. Furthermore, we integrated these markers with imaging-derived features, obtaining a better stratification of IDH-mutant glioma patients in comparison to histomolecular classification alone.< Réduire

Mots clés en anglais

IDH‐Mutant Glioma

Multimodal Integration

Proteomic

Radiomic

Transcriptomic

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https://oskar-bordeaux.fr/handle/20.500.12278/206631

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http://dx.doi.org/10.1002/ijc.35441

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A strategy for multimodal integration of transcriptomics, proteomics, and radiomics data for the prediction of recurrence in patients with IDH-mutant gliomas

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A strategy for multimodal integration of transcriptomics, proteomics, and radiomics data for the prediction of recurrence in patients with IDH-mutant gliomas

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