LÉONARD, Cédric; TATON, Benjamin; LAZARO, Estibaliz; MERVILLE, Pierre; VIALLARD, Jean-François; COUZI, Lionel; RIVIÈRE, Etienne

doi:10.3389/fimmu.2025.1519256

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

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Article de revue

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Frontiers in Immunology. 2025-01-01, vol. 16, p. 1519256

Résumé en anglais

Cytopenias occur frequently after kidney transplantation but posttransplantation thrombocytopenia (PTTCP) frequency has rarely been reported. This monocenter, retrospective study aimed to describe PTTCP frequency, causes, treatments and outcomes. PTTCP was defined as thrombocytopenia with ≥2 platelet counts <100×10/L after first month posttransplantation. Among 2118 kidney-transplant recipients between 2002 and 2018, 189 (8.9%) developed PTTCP. Their mean platelet-count nadir was 51×10/L [range 4-96×10]; nadir was <50×10/L for 87 (46.0%) patients. Main identified PTTCP etiologies were drugs (24.3%), or infectious diseases (20.1%; cytomegalovirus causing 79.4% of them), or unknown for 26 (13.7%). Bleeding rate was high (32.7%), with 40 (64.5%) severe episodes. During follow-up, 103 (54.5%) patients suffered graft loss or died at a median of 5.41 years post-PTTCP episode. Multivariate analyses retained a severe bleeding episode as being significantly associated with antiplatelet or anticoagulation therapy and pancytopenia, and age, creatininemia, transplantation-to-PTTCP interval and severe bleeding as significant risk factors for death or graft loss. PTTCP is frequently associated with severe bleeding, which is a risk factor for graft loss and death. Those findings suggest that the risk/benefit ratio of antiplatelet or anticoagulation therapies should be systemically evaluated for PTTCP patients.< Réduire

Mots clés en anglais

Humans

Kidney Transplantation

Male

Thrombocytopenia

Female

Middle Aged

Retrospective Studies

Aged

Adult

Risk Factors

Platelet Count

Postoperative Complications

Hemorrhage

URI

https://oskar-bordeaux.fr/handle/20.500.12278/206546

DOI

http://dx.doi.org/10.3389/fimmu.2025.1519256

Unités de recherche

Biologie des maladies cardiovasculaires (BMC) - UMR 1034

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Thrombocytopenia following kidney transplantation: a frequent, underestimated and potentially severe complication.

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Résumé en anglais

Mots clés en anglais

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Unités de recherche