UPADHYAY, Kamal Kumar; LE MEINS, Jean-Francois; MISRA, A.; VOISIN, Pierre; BOUCHAUD, Véronique; IBARBOURE, Emmanuel; SCHATZ, Christophe; LECOMMANDOUX, Sebastien

doi:10.1021/bm9006419

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UPADHYAY, Kamal Kumar
Pharm Dept, Fac Technol & Eng, Univ Baroda
Laboratoire de Chimie des Polymères Organiques [LCPO]

LE MEINS, Jean-Francois

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

MISRA, A.
Pharm Dept, Fac Technol & Eng, Univ Baroda

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Biomacromolecules. 2009, vol. 10, n° 10, p. 2802-2808

American Chemical Society

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Using "click chemistry" as an easy and versatile synthetic strategy to combine hyaluronan and polyglutamate blocks, we have prepared nanovesicles (polymersomes) that present a controlled size, excellent colloidal stability, and a high loading capacity for hydrophilic and hydrophobic drugs. The unique feature of our concept is the use of hyaluronan, a polysaccharide with known capacity for targeting cancer-related protein receptors, as the hydrophilic portion of a block copolymer system. The cytotoxicity and internalization mechanism of doxorubicin-loaded polymersomes have been evaluated in C6 glioma tumor cell lines. The dual purpose served by hyaluronan, as both a hydrophilic block critical to vesicle formation and as a binding agent for biological targets, breaks new ground in terms of multifunctional nanomaterial design for drug delivery.< Réduire

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biomimetic

targeting

vesicle

block copolymer

polysaccharide

polypeptide

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Biomimetic doxorubicin loaded polymersomes from hyaluronan-block-poly(gamma-benzyl glutamate) copolymers

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