"Click" Glycodendrimers Containing 27, 81, and 243 Modified Xylopyranoside Termini
CLOUTET, Eric
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 4 LCPO : Polymer Materials for Electronic, Energy, Information and Communication Technologies
< Réduire
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 4 LCPO : Polymer Materials for Electronic, Energy, Information and Communication Technologies
Langue
en
Article de revue
Ce document a été publié dans
Journal of Organic Chemistry. 2009, vol. 74, n° 14, p. 5071-5074
American Chemical Society
Résumé en anglais
A series of large glycodendrimers containing 27, 81, and 243 terminal modified xylose branches from the first (G1-27) to the third generation (G3-243) were synthesized from 2′-azidoethyl 2,3,4-tri-O-acetyl--D-xylopyranoside ...Lire la suite >
A series of large glycodendrimers containing 27, 81, and 243 terminal modified xylose branches from the first (G1-27) to the third generation (G3-243) were synthesized from 2′-azidoethyl 2,3,4-tri-O-acetyl--D-xylopyranoside and alkynyl-terminated dendrimers by "click" chemistry that is confirmed to be an excellent method to obtain large glycodendrimers exemplified by the use of modified xylose. The dendrimers were first characterized by 1H NMR, 13C{1H}NMR, elemental analysis, and IR spectroscopy. The size progression in the series was also demonstrated using both DOSY NMR and size exclusion chromatography (SEC), the latter technique showing the good polydispersity of all the dendrimers. The size measured by dynamic light scattering (DLS) for the dendrimer G3-243 is close to that obtained by the DOSY NMR method.< Réduire
Mots clés en anglais
click
glycodendrimer
xylose
Origine
Importé de halUnités de recherche