Studying microplastic transport in estuaries is challenging due to the dynamic interplay between river and ocean, compounded by the diverse properties exhibited by these particles. Lagrangian particle-tracking numerical modelling is a relevant tool for investigating microplastic transport dynamics, dispersion patterns, and vertical distribution. However, these models oversimplify the parametrizations of crucial estuarine processes by ignoring the effect of varying water density or vertical diffusion coefficients. In this study, we implement a hydrodynamic and improved particle tracking model in the macrotidal Gironde estuary (SW France) to explore the relative importance of different physical processes (time-space varying vertical diffusivity and water density, beaching-refloating, bottom resuspension) and provide a better understanding of microplastic dispersion and potential trapping. The simulated particle trajectories and density distributions from our findings indicate a limited influence of the spatio-temporal variability of vertical turbulence on floating particles, with a notable impact observed for settling particles, showing its significance in particle resuspension. Despite the time-space-varying water density, the effect on the transport patterns of both floating and settling microplastics is relatively lower, while the phenomenon of beaching-refloating increases the particle's residence time within the upper estuary. The higher river discharge during the spring season flushes floating particles downstream, with a portion reaching the open sea, while settling particles persist within the estuary during both seasons. Notably, denser microplastic particles tend to accumulate in the upper estuary region during summer, where the estuarine turbidity maxima have been identified.< Réduire