Towards a new approach in chiral resolution: Pressurized-CO2 assisted preferential cocrystallization
| dc.rights.license | open | en_US |
| dc.contributor.author | DE MEESTER, Josephine | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | LAYRISSE, Patrick | |
| dc.contributor.author | MARCHIVIE, Mathieu | |
| dc.contributor.author | COLLARD, Laurent | |
| dc.contributor.author | WERY, Guillaume | |
| dc.contributor.author | BRANDEL, Clement | |
| dc.contributor.author | CARTIGNY, Yohann | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | SUBRA-PATERNAULT, Pascale | |
| dc.contributor.author | LEYSSENS, Tom | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | HARSCOAT-SCHIAVO, Christelle | |
| dc.date.accessioned | 2025-04-04T12:23:46Z | |
| dc.date.available | 2025-04-04T12:23:46Z | |
| dc.date.issued | 2024-06-24 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/205981 | |
| dc.description.abstractEn | We here report the first occurrence of a preferential cocrystallization process assisted by compressed carbon dioxide. Our study focuses on the Nefiracetam-Mandelic acid conglomerate forming system. The cocrystal conglomerate was successfully crystallized using compressed CO2 as antisolvent, and acetone, ethyl acetate, or isobutanol as solvents for starting solutions in the so-called GAS process. We then focus on acetone to successfully perform preferential cocrystallization supported by compressed CO2. A critical step in the design of the process is the adaptation of the set-up to allow the introduction of enantiopure seeding inside the reactor. Based on the use of seeded rings, we test several seeding configurations to enhance enantioseparation through the simultaneous crystallization of both enantiomers in two different areas of the reactor. | |
| dc.description.sponsorship | Apport du CO2 dans le contrôle de phase cristalline - ANR-18-CE07-0047 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Antisolvent | |
| dc.subject.en | CO2 | |
| dc.subject.en | Cocrystal | |
| dc.subject.en | Conglomerate | |
| dc.subject.en | Preferential crystallization | |
| dc.subject.en | Seeding | |
| dc.title.en | Towards a new approach in chiral resolution: Pressurized-CO2 assisted preferential cocrystallization | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.supflu.2024.106339 | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| bordeaux.journal | Journal of Supercritical Fluids | en_US |
| bordeaux.page | 106339 | en_US |
| bordeaux.volume | 212 | en_US |
| bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
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