DE MEESTER, Josephine; LAYRISSE, Patrick; MARCHIVIE, Mathieu; COLLARD, Laurent; WERY, Guillaume; BRANDEL, Clement; CARTIGNY, Yohann; SUBRA-PATERNAULT, Pascale; LEYSSENS, Tom; HARSCOAT-SCHIAVO, Christelle

doi:10.1016/j.supflu.2024.106339

LAYRISSE, Patrick
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

MARCHIVIE, Mathieu

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Article de revue

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Journal of Supercritical Fluids. 2024-06-24, vol. 212, p. 106339

Resumen en inglés

We here report the first occurrence of a preferential cocrystallization process assisted by compressed carbon dioxide. Our study focuses on the Nefiracetam-Mandelic acid conglomerate forming system. The cocrystal conglomerate was successfully crystallized using compressed CO2 as antisolvent, and acetone, ethyl acetate, or isobutanol as solvents for starting solutions in the so-called GAS process. We then focus on acetone to successfully perform preferential cocrystallization supported by compressed CO2. A critical step in the design of the process is the adaptation of the set-up to allow the introduction of enantiopure seeding inside the reactor. Based on the use of seeded rings, we test several seeding configurations to enhance enantioseparation through the simultaneous crystallization of both enantiomers in two different areas of the reactor.< Leer menos

Palabras clave en inglés

Antisolvent

CO2

Cocrystal

Conglomerate

Preferential crystallization

Seeding

URI

https://oskar-bordeaux.fr/handle/20.500.12278/205981

DOI

http://dx.doi.org/10.1016/j.supflu.2024.106339

Proyecto ANR

Apport du CO2 dans le contrôle de phase cristalline - ANR-18-CE07-0047

Centros de investigación

CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248

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Towards a new approach in chiral resolution: Pressurized-CO2 assisted preferential cocrystallization