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Towards a new approach in chiral resolution: Pressurized-CO2 assisted preferential cocrystallization
Language
EN
Article de revue
This item was published in
Journal of Supercritical Fluids. 2024-06-24, vol. 212, p. 106339
English Abstract
We here report the first occurrence of a preferential cocrystallization process assisted by compressed carbon dioxide. Our study focuses on the Nefiracetam-Mandelic acid conglomerate forming system. The cocrystal conglomerate ...Read more >
We here report the first occurrence of a preferential cocrystallization process assisted by compressed carbon dioxide. Our study focuses on the Nefiracetam-Mandelic acid conglomerate forming system. The cocrystal conglomerate was successfully crystallized using compressed CO2 as antisolvent, and acetone, ethyl acetate, or isobutanol as solvents for starting solutions in the so-called GAS process. We then focus on acetone to successfully perform preferential cocrystallization supported by compressed CO2. A critical step in the design of the process is the adaptation of the set-up to allow the introduction of enantiopure seeding inside the reactor. Based on the use of seeded rings, we test several seeding configurations to enhance enantioseparation through the simultaneous crystallization of both enantiomers in two different areas of the reactor.Read less <
English Keywords
Antisolvent
CO2
Cocrystal
Conglomerate
Preferential crystallization
Seeding
ANR Project
Apport du CO2 dans le contrôle de phase cristalline - ANR-18-CE07-0047