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A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes in male mice

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFERNÁNDEZ-MONCADA, Ignacio
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLAVANCO, Gianluca
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFUNDAZURI, Unai B
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBOLLMOHR, Nasrin
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMOUNTADEM, Sarah
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDALLA TOR, Tommaso
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorHACHAGUER, Pauline
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorJULIO-KALAJZIC, Francisca
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorGISQUET, Doriane
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorSERRAT, Roman
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBELLOCCHIO, Luigi
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCANNICH, Astrid
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFORTUNATO-MARSOL, Bérénice
dc.contributor.authorNASU, Yusuke
dc.contributor.authorCAMPBELL, Robert E
dc.contributor.authorDRAGO, Filippo
dc.contributor.authorCANNIZZARO, Carla
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorFERREIRA, Guillaume
dc.contributor.authorBOUZIER-SORE, Anne-Karine
dc.contributor.authorPELLERIN, Luc
dc.contributor.authorBOLAÑOS, Juan P
dc.contributor.authorBONVENTO, Gilles
dc.contributor.authorBARROS, L. Felipe
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorOLIET, Stephane H R
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPANATIER, Aude
dc.contributor.authorMARSICANO, Giovanni
dc.date.accessioned2025-03-19T09:49:34Z
dc.date.available2025-03-19T09:49:34Z
dc.date.issued2024-08
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/205558
dc.description.abstractEnAstrocytes control brain activity via both metabolic processes and gliotransmission, but the physiological links between these functions are scantly known. Here we show that endogenous activation of astrocyte type-1 cannabinoid (CB1) receptors determines a shift of glycolysis towards the lactate-dependent production of d-serine, thereby gating synaptic and cognitive functions in male mice. Mutant mice lacking the CB1 receptor gene in astrocytes (GFAP-CB1-KO) are impaired in novel object recognition (NOR) memory. This phenotype is rescued by the gliotransmitter d-serine, by its precursor l-serine, and also by lactate and 3,5-DHBA, an agonist of the lactate receptor HCAR1. Such lactate-dependent effect is abolished when the astrocyte-specific phosphorylated-pathway (PP), which diverts glycolysis towards l-serine synthesis, is blocked. Consistently, lactate and 3,5-DHBA promoted the co-agonist binding site occupancy of CA1 post-synaptic NMDA receptors in hippocampal slices in a PP-dependent manner. Thus, a tight cross-talk between astrocytic energy metabolism and gliotransmission determines synaptic and cognitive processes.
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004en_US
dc.description.sponsorshipInvolvement of the insula in the Autism neurodevelopmental disorderen_US
dc.description.sponsorshipRécepteurs CB1, bioénergétique et mémoire : une nouvelle interaction métabolique entre le lactate et la sérineen_US
dc.description.sponsorshipRôle du système endocannabinoïde de l'hippocampe dans le déficits de mémoire associés à l'obésitéen_US
dc.description.sponsorshipRôle des différents substrats énergétiques pour l'activité cérébrale - ANR-21-CE44-0023en_US
dc.description.sponsorshipRôle et Physiologie Cellulaire de Nouveaux Récepteurs Glycine Excitateurs dans le Cerveau Antérieuren_US
dc.description.sponsorshipLes exosomes, un nouveau mode de communication entre les astrocytes et les neurones avec de possibles implications dans la maladie d'Alzheimeren_US
dc.description.sponsorshipRole du recepteur CB1 mitocondriel du tissue adipeux dans la regulation de la balance energetiqueen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.title.enA lactate-dependent shift of glycolysis mediates synaptic and cognitive processes in male mice
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41467-024-51008-2en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed39122700en_US
bordeaux.journalNature Communicationsen_US
bordeaux.page6842en_US
bordeaux.volume15en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.institutionINSERM
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Communications&rft.date=2024-08&rft.volume=15&rft.issue=1&rft.spage=6842&rft.epage=6842&rft.au=FERN%C3%81NDEZ-MONCADA,%20Ignacio&LAVANCO,%20Gianluca&FUNDAZURI,%20Unai%20B&BOLLMOHR,%20Nasrin&MOUNTADEM,%20Sarah&rft.genre=article


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