Temperature responsive poly(trimethylene carbonate)-block-poly(L-glutamic acid) copolymer: polymersomes fusion and fission
LE MEINS, Jean-Francois
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
SCHATZ, Christophe
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Leer más >
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
LE MEINS, Jean-Francois
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
SCHATZ, Christophe
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
SOUM, Alain
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Leer menos
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Idioma
en
Article de revue
Este ítem está publicado en
Soft Matter. 2010, vol. 6, n° 8, p. 1722-1730
Royal Society of Chemistry
Resumen en inglés
We have reported on a new type of thermotropic transition in synthetic diblock copolymer vesicles. Vesicles were self-assembled from a well-defined poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC22-b-PGA14, M(n) ...Leer más >
We have reported on a new type of thermotropic transition in synthetic diblock copolymer vesicles. Vesicles were self-assembled from a well-defined poly(trimethylene carbonate)-b-poly(L-glutamic acid) (PTMC22-b-PGA14, M(n) = 4.05*10(3) g mol(-1)) copolymer. PTMC(22) is a semi-crystalline hydrophobic block with a melting endotherm observed at 37 degrees C in the bulk copolymer and at 34-35 degrees C in the vesicular dispersions. This temperature transition, as observed by mDSC in the aqueous vesicular dispersions, arose from a variation of the PTMC chain packing inside the vesicular bilayer. A large range of vesicle sizes, from 100 nm to 5 mu m, was accessible by varying the experimental conditions to prepare the vesicles. Large vesicles were more sensitive to the melting transition due to a low membrane curvature and high hydrophobic block interactions. By many aspects, this transition presented strong analogies with the gel-to-liquid crystalline phase transition observed in liposomes. Vesicle budding and fission occurred when temperature was increased above the PTMC melting temperature and fusion events were observed when temperature was decreased. The fission process was certainly due to the creation of an excess area upon heating whereas fusion is due to membrane defects arising from variation in PTMC membrane packing. As a consequence, the size of the vesicles was found correlated to the crystalline state of the PTMC chains, its variation being fully reversible with the temperature.< Leer menos
Palabras clave en inglés
CRYSTALLINE PHASE-TRANSITION
BLOCK-COPOLYMERS
DIPALMITOYLPHOSPHATIDYLCHOLINE VESICLES
DIBLOCK COPOLYMERS
BIOLOGICAL-MEMBRANES
LIPID-BILAYERS
ACYL CHAINS
MICELLES
DISPERSIONS
MORPHOLOGY
Orígen
Importado de HalCentros de investigación