FENG, Xiaoshuang; L. CHAIKOF, Elliot; ABSALON, Christelle; DRUMMOND, Carlos; TATON, Daniel; GNANOU, Yves

doi:10.1002/marc.201100459

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FENG, Xiaoshuang
Laboratoire de Chimie des polymères organiques [LCPO]

L. CHAIKOF, Elliot
Department of Surgery

ABSALON, Christelle
Institut des Sciences Moléculaires [ISM]

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Macromolecular Rapid Communications. 2011, vol. 32, p. pp. 1722-1728

Wiley-VCH Verlag

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Degradable dendrimer-like PEO's were designed using an original ABC-type branching agent featuring a cleavable ketal group, following an iterative divergent approach based on the anionic ring opening polymerization (AROP) of ethylene oxide and arborization of PEO chain ends. A seventh generation dendrimer-like PEO carrying 192 peripheral hydroxyls and exhibiting a molar mass of 446 kg -1 mol-1 was obtained in this way. The chemical degradation of these dendritic scaffolds was next successfully accomplished under acidic conditions, forming linear PEO chains of low molar mass (2kg. mol-1), as monitored by 1H NMR, SEC, and MALDI-TOF mass spectrometry as well as by AFM.< Réduire

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Dendritic Carrier Based on PEG: Design and Degradation of Acid-sensitive Dendrimer-like Poly(ethylene oxide)sa

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