Separation study of organic bases on new polymeric stationary phases under basic conditions
HÉROGUEZ, Valérie
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
HÉROGUEZ, Valérie
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
< Réduire
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Langue
en
Article de revue
Ce document a été publié dans
European Polymer Journal. 2012, vol. 48, n° 1, p. 228-234
Elsevier
Résumé en anglais
Crosslinked monodisperse polymer microparticles have been synthesized and evaluated as stationary phases for the separation of basic drug molecules in reversed-phase high performance liquid chromatography. The polymer beads ...Lire la suite >
Crosslinked monodisperse polymer microparticles have been synthesized and evaluated as stationary phases for the separation of basic drug molecules in reversed-phase high performance liquid chromatography. The polymer beads were prepared by free-radical copolymerization of divinylbenzene and styrene or vinylbenzyl chloride in acetonitrile with toluene as porogen agent using the precipitation method. Their efficiency as stationary phase was investigated at both acid (5.6) and basic (12) pH, and the results compared with those of a commercial polymeric reversed-phase column. Separation of the organic bases was achieved with the chlorobenzyl particles at pH 12. (C) 2011 Elsevier Ltd. All rights reserved.< Réduire
Mots clés en anglais
Polymer stationary phase
Precipitation polymerization
Liquid chromatography
Organic bases
Basic pH
Origine
Importé de halUnités de recherche