NGUYEN, Minh Ngoc; LEBARBÉ, Thomas; ZOUANI, Omar Farouk; PICHAVANT, Loïc; DURRIEU, Marie-Christine; HÉROGUEZ, Valérie

doi:10.1021/bm201812u

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NGUYEN, Minh Ngoc
Laboratoire de Chimie des Polymères Organiques [LCPO]

LEBARBÉ, Thomas
Laboratoire de Chimie des Polymères Organiques [LCPO]

ZOUANI, Omar Farouk

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Biomacromolecules. 2012, vol. 13, n° 3, p. 896-904

American Chemical Society

Résumé en anglais

This work reports on the synthesis of titanium bone implants functionalized with nanoparticles (NPs) containing Arg-Gly-Asp-Cys peptide (RGDC) and shows the adhesion behavior of cells seeded on these materials. RGDC peptides were first: conjugated to a norbornenyl-poly(ethylene oxide) macromonomer (Nb-PEO). Then, functional NPs with a size of similar to 300 nm and constituted of polynorbornene core surrounded by poly(ethylene oxide) shell were prepared by ring-opening metathesis polymerization in dispersed medium. The grafting density of these NPs on the titanium surface is up to 2 NPs.mu m(-2) (80 pmol of RGDC per cm(-2) of NP surface). Cell adhesion was evaluated using preosteoblast cells (MC3T3-E1). Results of cells cultured for 24 h showed that materials grafted with NPs functionalized with RGDC peptides enhance specific cell adhesion and can create filopodia-like among NP sites by stressing the cells.< Réduire

Mots clés en anglais

BIOMATERIALS

VIVO

IMPLANTS

OPENING METATHESIS POLYMERIZATION

IN-VITRO

BONE-FORMATION

PEPTIDES

SURFACES

DIFFERENTIATION

HYDROGELS

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Impact of RGD Nanopatterns Grafted onto Titanium on Osteoblastic Cell Adhesion

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