BERTHELOT, Karine; ESTEVEZ, Yannick; DEFFIEUX, Alain; PERUCH, Frédéric

doi:10.1016/j.biochi.2012.03.021

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BERTHELOT, Karine
Laboratoire de Chimie des Polymères Organiques [LCPO]

ESTEVEZ, Yannick
Laboratoire de Chimie des Polymères Organiques [LCPO]

DEFFIEUX, Alain
Laboratoire de Chimie des Polymères Organiques [LCPO]

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Biochimie. 2012, vol. 94, n° 8, p. 1621-1634

Elsevier

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Even if the isopentenyl diphosphate (IPP) isomerases have been discovered in the 50s, it is only in the last decade that the genetical, enzymatical, structural richness and cellular importance of this large family of crucial enzymes has been uncovered. Present in all living kingdoms, they can be classified in two subfamilies: type 1 and type 2 IPP isomerases, which show clearly distinct characteristics. They all perform the regulatory isomerization of isopentenyl diphosphate into dimethylallyl diphosphate, a key rate-limiting step of the terpenoid biosynthesis, via a protonation/deprotonation mechanism. Due to their importance in the isoprenoid metabolism and the increasing interest of industry devoted to terpenoid production, it is foreseen that the biotechnological development of such enzymes should be under intense scrutiny in the near future.< Leer menos

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Terpens

Isoprenoid synthesis

Isopentenyl diphosphate isomerase

IPP

DMAPP

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Isopentenyl diphosphate isomerase: A checkpoint to isoprenoid biosynthesis

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