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Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus

hal.structure.identifierRégulation spatiale des Génomes - Spatial Regulation of Genomes
hal.structure.identifierCollège Doctoral
dc.contributor.authorMENEU, Léa
hal.structure.identifierRégulation spatiale des Génomes - Spatial Regulation of Genomes
dc.contributor.authorCHAPARD, Christophe
hal.structure.identifierRégulation spatiale des Génomes - Spatial Regulation of Genomes
dc.contributor.authorSERIZAY, Jacques
hal.structure.identifierStructure et Instabilité des Génomes [STRING]
dc.contributor.authorWESTBROOK, Alex
hal.structure.identifierCollège Doctoral
hal.structure.identifierStructure et Instabilité des Génomes [STRING]
hal.structure.identifierLaboratoire de Physique Théorique de la Matière Condensée [LPTMC]
dc.contributor.authorROUTHIER, Etienne
hal.structure.identifierDynamique du noyau [Institut Curie]
dc.contributor.authorRUAULT, Myriam
hal.structure.identifierRégulation spatiale des Génomes - Spatial Regulation of Genomes
hal.structure.identifierCollège Doctoral
dc.contributor.authorPERROT, Manon
hal.structure.identifierInstitut de Génétique Moléculaire de Montpellier [IGMM]
dc.contributor.authorMINAKAKIS, Alexandros
hal.structure.identifierRégulation spatiale des Génomes - Spatial Regulation of Genomes
dc.contributor.authorGIRARD, Fabien
hal.structure.identifierRégulation spatiale des Génomes - Spatial Regulation of Genomes
hal.structure.identifierCollège Doctoral
dc.contributor.authorBIGNAUD, Amaury
hal.structure.identifierDynamique du noyau [Institut Curie]
dc.contributor.authorEVEN, Antoine
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorGOURGUES, Géraldine
hal.structure.identifierInstitut de Génétique Moléculaire de Montpellier [IGMM]
dc.contributor.authorLIBRI, Domenico
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorLARTIGUE, Carole
hal.structure.identifierRégulation spatiale des Génomes - Spatial Regulation of Genomes
dc.contributor.authorPIAZZA, Aurèle
hal.structure.identifierRégulation spatiale des Génomes - Spatial Regulation of Genomes
dc.contributor.authorTHIERRY, Agnès
hal.structure.identifierDynamique du noyau [Institut Curie]
dc.contributor.authorTADDEI, Angela
hal.structure.identifierUnité de biologie Moléculaire, Cellulaire et du Développement [MCD]
dc.contributor.authorBECKOUËT, Frédéric
hal.structure.identifierStructure et Instabilité des Génomes [STRING]
hal.structure.identifierLaboratoire de Physique Théorique de la Matière Condensée [LPTMC]
hal.structure.identifierAcquisition et Analyse de Données pour l'Histoire naturelle [2AD]
dc.contributor.authorMOZZICONACCI, Julien
hal.structure.identifierRégulation spatiale des Génomes - Spatial Regulation of Genomes
dc.contributor.authorKOSZUL, Romain
dc.date.issued2025-02-07
dc.identifier.issn0036-8075
dc.description.abstractEnIn eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and activity of chromatin components in the absence of coevolution. Using bacterial genomes integrated into Saccharomyces cerevisiae , which diverged from yeast more than 2 billion years ago, we show that nucleosomes, cohesins, and associated transcriptional machinery can lead to the formation of two different chromatin archetypes, one transcribed and the other silent, independently of heterochromatin formation. These two archetypes also form on eukaryotic exogenous sequences, depend on sequence composition, and can be predicted using neural networks trained on the native genome. They do not mix in the nucleus, leading to a bipartite nuclear compartmentalization, reminiscent of the organization of vertebrate nuclei.
dc.description.sponsorshipAmplification des centrioles: Nature, conséquences et acteurs moléculaires impliqués dans les réarrangements chromosomique et cytoplasmique - ANR-19-CE13-0027
dc.description.sponsorshipDécryptage des déterminants permettant le repliement du génome sous l'action de la cohésine - ANR-22-CE12-0013
dc.description.sponsorshipDistanciation Génomique chez la levure - ANR-21-CE12-0040
dc.description.sponsorshipOrganisation et montée en puissance d'une Infrastructure Nationale de Génomique
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnée
dc.language.isoen
dc.publisherAmerican Association for the Advancement of Science (AAAS)
dc.title.enSequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
dc.typeArticle de revue
dc.identifier.doi10.1126/science.adm9466
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie
dc.description.sponsorshipEuropeInvestigating the functional architecture of microbial genomes with synthetic approaches
bordeaux.journalScience
bordeaux.pageeadm9466
bordeaux.volume387
bordeaux.issue6734
bordeaux.peerReviewedoui
hal.identifierhal-04937691
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04937691v1
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