MENEU, Léa; CHAPARD, Christophe; SERIZAY, Jacques; WESTBROOK, Alex; ROUTHIER, Etienne; RUAULT, Myriam; PERROT, Manon; MINAKAKIS, Alexandros; GIRARD, Fabien; BIGNAUD, Amaury; EVEN, Antoine; GOURGUES, Géraldine; LIBRI, Domenico; LARTIGUE, Carole; PIAZZA, Aurèle; THIERRY, Agnès; TADDEI, Angela; BECKOUËT, Frédéric; MOZZICONACCI, Julien; KOSZUL, Romain

doi:10.1126/science.adm9466

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MENEU, Léa
Régulation spatiale des Génomes - Spatial Regulation of Genomes
Collège Doctoral

CHAPARD, Christophe
Régulation spatiale des Génomes - Spatial Regulation of Genomes

SERIZAY, Jacques
Régulation spatiale des Génomes - Spatial Regulation of Genomes

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Este ítem está publicado en

Science. 2025-02-07, vol. 387, n° 6734, p. eadm9466

American Association for the Advancement of Science (AAAS)

Resumen en inglés

In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and activity of chromatin components in the absence of coevolution. Using bacterial genomes integrated into Saccharomyces cerevisiae , which diverged from yeast more than 2 billion years ago, we show that nucleosomes, cohesins, and associated transcriptional machinery can lead to the formation of two different chromatin archetypes, one transcribed and the other silent, independently of heterochromatin formation. These two archetypes also form on eukaryotic exogenous sequences, depend on sequence composition, and can be predicted using neural networks trained on the native genome. They do not mix in the nucleus, leading to a bipartite nuclear compartmentalization, reminiscent of the organization of vertebrate nuclei.< Leer menos

DOI

http://dx.doi.org/10.1126/science.adm9466

Proyecto europeo

Investigating the functional architecture of microbial genomes with synthetic approaches

Proyecto ANR

Amplification des centrioles: Nature, conséquences et acteurs moléculaires impliqués dans les réarrangements chromosomique et cytoplasmique
Décryptage des déterminants permettant le repliement du génome sous l'action de la cohésine - ANR-22-CE12-0013
Distanciation Génomique chez la levure - ANR-21-CE12-0040
Organisation et montée en puissance d'une Infrastructure Nationale de Génomique
Développment d'une infrastructure française distribuée coordonnée

Orígen

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Centros de investigación

Biologie du Fruit & Pathologie (BFP) - UMR 1332