Synthesis and self-assembly of "tree-like" amphiphilic glycopolypeptides
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Réduire
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Langue
en
Article de revue
Ce document a été publié dans
Chemical Communications. 2012, vol. 48, n° 67, p. 8353-8355
Royal Society of Chemistry
Résumé en anglais
Novel synthetic tree-like oligosaccharides-grafted-polypeptides were prepared by using Huisgen 1,3-dipolar cycloaddition between poly(gamma-benzyl-L-glutamate)-block-poly(propargylglycine) and two different oligosaccharides, ...Lire la suite >
Novel synthetic tree-like oligosaccharides-grafted-polypeptides were prepared by using Huisgen 1,3-dipolar cycloaddition between poly(gamma-benzyl-L-glutamate)-block-poly(propargylglycine) and two different oligosaccharides, dextran or hyaluronan. By direct solubilisation in water, these tree- ike glycopeptides spontaneously form very small assemblies with sizes below 50 nm and low polydispersity.< Réduire
Mots clés en anglais
MICELLES
GLYCOPOLYMERS
DOXORUBICIN
BLOCK-COPOLYMERS
DRUG-DELIVERY
VESICLES
POLYMERSOMES
WATER
Origine
Importé de halUnités de recherche