Domain Swapping in Abiotic Foldamers
| dc.rights.license | open | en_US |
| dc.contributor.author | WANG, Shuhe | |
| dc.contributor.author | WICHER, Barbara | |
| dc.contributor.author | DOUAT, Celine | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | MAURIZOT, Victor | |
| dc.contributor.author | HUC, Ivan | |
| dc.date.accessioned | 2025-01-21T11:01:46Z | |
| dc.date.available | 2025-01-21T11:01:46Z | |
| dc.date.issued | 2024-06-08 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/204448 | |
| dc.description.abstractEn | Foldamer sequences that adopt tertiary helix‐turn‐helix folds mediated by helix‐helix hydrogen bonding in organic solvents have been previously reported. In an attempt to create genuine abiotic quaternary structures, i.e. assemblies of tertiary structures, new sequences were prepared that possess additional hydrogen bond donors at positions that may promote an association between the tertiary folds. However, a solid state structure and extensive solution state investigations by Nuclear Magnetic Resonance (NMR) and Circular Dichroism (CD) show that, instead of forming a quaternary structure, the tertiary folds assemble into stable domain‐swapped dimer motifs. Domain swapping entails a complete reorganization of the arrays of hydrogen bonds and changes in relative helix orientation and handedness that can all be rationalized. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Abiotic foldamer | |
| dc.subject.en | Domain swapping | |
| dc.subject.en | Hydrogen bonding | |
| dc.subject.en | Structure elucidation | |
| dc.subject.en | Tertiary structure | |
| dc.title.en | Domain Swapping in Abiotic Foldamers | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/anie.202405091 | en_US |
| dc.subject.hal | Chimie/Matériaux | en_US |
| dc.identifier.pubmed | 38661252 | en_US |
| bordeaux.journal | Angewandte Chemie International Edition | en_US |
| bordeaux.page | 25150 - 25159 | en_US |
| bordeaux.volume | 63 | en_US |
| bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
| bordeaux.issue | 28 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY-NC | en_US |
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