WANG, Shuhe; WICHER, Barbara; DOUAT, Celine; MAURIZOT, Victor; HUC, Ivan

doi:10.1002/anie.202405091

Idioma

Article de revue

Este ítem está publicado en

Angewandte Chemie International Edition. 2024-06-08, vol. 63, n° 28, p. 25150 - 25159

Resumen en inglés

Foldamer sequences that adopt tertiary helix‐turn‐helix folds mediated by helix‐helix hydrogen bonding in organic solvents have been previously reported. In an attempt to create genuine abiotic quaternary structures, i.e. assemblies of tertiary structures, new sequences were prepared that possess additional hydrogen bond donors at positions that may promote an association between the tertiary folds. However, a solid state structure and extensive solution state investigations by Nuclear Magnetic Resonance (NMR) and Circular Dichroism (CD) show that, instead of forming a quaternary structure, the tertiary folds assemble into stable domain‐swapped dimer motifs. Domain swapping entails a complete reorganization of the arrays of hydrogen bonds and changes in relative helix orientation and handedness that can all be rationalized.< Leer menos

Palabras clave en inglés

Abiotic foldamer

Domain swapping

Hydrogen bonding

Structure elucidation

Tertiary structure

URI

https://oskar-bordeaux.fr/handle/20.500.12278/204448

DOI

http://dx.doi.org/10.1002/anie.202405091

Centros de investigación

CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248

Ver/Abrir

Metadatos

Compartir este ítem

Licencia de uso del documento

Domain Swapping in Abiotic Foldamers

Idioma

Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Centros de investigación