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dc.rights.licenseopenen_US
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorDESIGAUX, Theo
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorCOMPERAT, Leo
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorDUSSERRE, Nathalie
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorSTACHOWICZ, Marie-Laure
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorLEA, Malou
dc.contributor.authorDUPUY, Jean-William
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorVIAL, Anthony
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorMOLINARI, Michael
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorFRICAIN, Jean-Christophe
dc.contributor.authorPARIS, François
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorOLIVEIRA, Hugo
dc.date.accessioned2025-01-20T16:34:16Z
dc.date.available2025-01-20T16:34:16Z
dc.date.issued2024-12-01
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/204418
dc.description.abstractEnDeciphering breast cancer treatment resistance remains hindered by the lack of models that can successfully capture the four-dimensional dynamics of the tumor microenvironment. Here, we show that microextrusion bioprinting can reproducibly generate distinct cancer and stromal compartments integrating cells relevant to human pathology. Our findings unveil the functional maturation of this millimeter-sized model, showcasing the development of a hypoxic cancer core and an increased surface proliferation. Maturation was also driven by the presence of cancer-associated fibroblasts (CAF) that induced elevated microvascular-like structures complexity. Such modulation was concomitant to extracellular matrix remodeling, with high levels of collagen and matri- cellular proteins deposition by CAF, simultaneously increasing tumor stiffness and recapitulating breast cancer fibrotic development. Importantly, our bioprinted model faithfully reproduced response to treatment, further modulated by CAF. Notably, CAF played a protective role for cancer cells against radiotherapy, facilitating increased paracrine communications. This model holds promise as a platform to decipher interactions within the microenvironment and evaluate stroma-targeted drugs in a context relevant to human pathology.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enBioprinting
dc.subject.enCancer microenvironment
dc.subject.enExtracellular matrix
dc.title.en3D bioprinted breast cancer model reveals stroma-mediated modulation of extracellular matrix and radiosensitivity
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.bioactmat.2024.08.037en_US
dc.subject.halChimie/Matériauxen_US
dc.identifier.pubmed39290339en_US
dc.description.sponsorshipEuropeFondation ARC pour la recherche sur le canceren_US
bordeaux.journalBioactive Materialsen_US
bordeaux.page316-327en_US
bordeaux.volume42en_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERM
bordeaux.institutionCHU de Bordeaux
bordeaux.institutionInstitut Bergonié
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Bioactive%20Materials&rft.date=2024-12-01&rft.volume=42&rft.spage=316-327&rft.epage=316-327&rft.au=DESIGAUX,%20Theo&COMPERAT,%20Leo&DUSSERRE,%20Nathalie&STACHOWICZ,%20Marie-Laure&LEA,%20Malou&rft.genre=article


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