FENG, Xiaoshuang; CHAIKOF, Elliot L.; ABSALON, Christelle; DRUMMOND, Carlos; TATON, Daniel; GNANOU, Yves

doi:10.1002/marc.201100459

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FENG, Xiaoshuang
Laboratoire de Chimie des Polymères Organiques [LCPO]

CHAIKOF, Elliot L.
Dept Surg, BethIsrael Deaconess Med Ctr [Harvard Univ, Sch Med]

ABSALON, Christelle
Institut des Sciences Moléculaires [ISM]

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Macromolecular Rapid Communications. 2011, vol. 32, n° 21, p. 1722-1728

Wiley-VCH Verlag

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Degradable dendrimer-like PEO's were designed using an original ABC-type branching agent featuring a cleavable ketal group, following an iterative divergent approach based on the anionic ring opening polymerization (AROP) of ethylene oxide and arborization of PEO chain ends. A seventh generation dendrimer-like PEO carrying 192 peripheral hydroxyls and exhibiting a molar mass of 446 kg . mol(-1) was obtained in this way. The chemical degradation of these dendritic scaffolds was next successfully accomplished under acidic conditions, forming linear PEO chains of low molar mass (approximate to 2 kg . mol(-1)), as monitored by H-1 NMR, SEC, and MALDI-TOF mass spectrometry as well as by AFM.< Réduire

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Dendritic Carrier Based on PEG: Design and Degradation of Acid-sensitive Dendrimer-like Poly(ethylene oxide)s

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