KONSMAN, Jan Pieter

doi:10.1016/j.shpsa.2023.12.002

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KONSMAN, Jan Pieter
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

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Studies in History and Philosophy of Science. 2024-02, vol. 103, p. 123 – 136

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Evidence-Based Medicine has little consideration for mechanisms and philosophers of science and medicine have recently made pleas to increase the place of mechanisms in the medical evidence hierarchy. However, in this debate the notions of mechanisms seem to be limited to ‘mechanistic processes’ and ‘complex-systems mechanisms,’ understood as ‘componential causal systems’. I believe that this will not do full justice to how mechanisms are used in biological, psychological and social sciences and, consequently, in a more biopsychosocial approach to medicine. Here, I propose, following (Kuorikoski, 2009), to pay more attention to ‘abstract forms of interaction’ mechanisms. The present work scrutinized review articles on depression and medically unexplained pain, which are considered to be of multifactorial pathogenesis, for their use of mechanisms. In review articles on these disorders there seemed to be a range of uses between more ‘abstract forms of interaction’ and ‘componential causal system’ mechanisms. I therefore propose to expand the notions of mechanisms considered in medicine to include that of more ‘abstract forms of interaction’ to better explain and manage biopsychosocial disorders.< Réduire

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Expanding the notion of mechanism to further understanding of biopsychosocial disorders? Depression and medically-unexplained pain as cases in point

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