Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis
| dc.rights.license | open | en_US |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | GOUNOU, Celine | |
| dc.contributor.author | ROUYER, Lucile | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | SIEGFRIED, Geraldine | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | HARTE, Etienne | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BOUVET, Flora | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | D'AGATA, Lena | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | DARBO, Elodie | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | LEFEUVRE, Martin | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | DERIEPPE, M | |
| dc.contributor.author | BOUTON, Lea | |
| dc.contributor.author | MELANE, Mailys | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | CHAPEAU, Dorian | |
| dc.contributor.author | MARTINEAU, Julie | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | PROUZET-MAULEON, Valerie | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | TAN, Sisareuth | |
| dc.contributor.author | SOULEYREAU, Wilfried | |
| dc.contributor.author | SALTEL, Frederic | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | ARGOUL, Francoise | |
| dc.contributor.author | KHATIB, Abdel‐majid | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BRISSON, Alain | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | IGGO, Richard | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | BOUTER, Anthony | |
| dc.date.accessioned | 2024-12-19T09:54:28Z | |
| dc.date.available | 2024-12-19T09:54:28Z | |
| dc.date.issued | 2023-12-13 | |
| dc.identifier.issn | 1420-682X | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/204003 | |
| dc.description.abstractEn | Cancer cells are exposed to major compressive and shearing forces during invasion and metastasis, leading to extensive plasma membrane damage. To survive this mechanical stress, they need to repair membrane injury efficiently. Targeting the membrane repair machinery is thus potentially a new way to prevent invasion and metastasis. We show here that annexin-A2 (ANXA2) is required for membrane repair in invasive breast and pancreatic cancer cells. Mechanistically, we show by fluorescence and electron microscopy that cells fail to reseal shear-stress damaged membrane when ANXA2 is silenced or the protein is inhibited with neutralizing antibody. Silencing of ANXA2 has no effect on proliferation in vitro, and may even accelerate migration in wound healing assays, but reduces tumor cell dissemination in both mice and zebrafish. We expect that inhibiting membrane repair will be particularly effective in aggressive, poor prognosis tumors because they rely on the membrane repair machinery to survive membrane damage during tumor invasion and metastasis. This could be achieved either with anti-ANXA2 antibodies, which have been shown to inhibit metastasis of breast and pancreatic cancer cells, or with small molecule drugs. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Annexins | |
| dc.subject.en | Invasion | |
| dc.subject.en | Metastasis | |
| dc.subject.en | Tumor progression | |
| dc.subject.en | S100 proteins | |
| dc.subject.en | MDA-MB-231 | |
| dc.subject.en | AsPC-1 | |
| dc.title.en | Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s00018-023-05049-3 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire | en_US |
| bordeaux.journal | Cellular and Molecular Life Sciences | en_US |
| bordeaux.page | 7 | en_US |
| bordeaux.volume | 81 | en_US |
| bordeaux.hal.laboratories | CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-04687405 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | CC BY-NC-ND | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cellular%20and%20Molecular%20Life%20Sciences&rft.date=2023-12-13&rft.volume=81&rft.issue=1&rft.spage=7&rft.epage=7&rft.eissn=1420-682X&rft.issn=1420-682X&rft.au=GOUNOU,%20Celine&ROUYER,%20Lucile&SIEGFRIED,%20Geraldine&HARTE,%20Etienne&BOUVET,%20Flora&rft.genre=article |
