KAIJANSINKKO, Henna; BONTHUIS, Marjolein; JAHNUKAINEN, Kirsi; HARAMBAT, Jerome; VIDAL, Enrico; BAKKALOGLU, Sevcan A; INWARD, Carol; SINHA, Manish D; ROPERTO, Rosa M; KUEHNI, Claudia E; BIRO, Erika; KWON, Theresa; MOTA, Conceicao; ADAMS, Brigitte; SZCZEPANSKA, Maria; BIENIAS, Beata; HOCKER, Britta; FOMINA, Svitlana; GJERSTAD, Ann Christin; VONDRAK, Karel; ALPAY, Harika; PLUMB, Lucy A; HOMMEL, Kristine; MOLCHANOVA, Maria S; HUBMANN, Holger; ALONSO-MELGAR, Angel; JAGER, Kitty J; JAHNUKAINEN, Timo

doi:10.1016/j.ajt.2024.11.002

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American Journal of Transplantation. 2024-11-07

Résumé en anglais

Cancer and its treatment may lead to kidney injury and need for kidney replacement therapy (KRT). We identified 287 pediatric KRT patients with a malignancy history from the ESPN/ERA Registry. Of these, 197 had cancer as a primary cause of KRT (group 1) and 90 had a malignancy diagnosis before KRT (group 2). Two matched controls without malignancy were randomly selected for each patient. Data were complemented with a questionnaire. Median time to kidney transplantation (KT) from KRT initiation was 2.4 (IQR: 1.5-4.7), 1.5 (IQR: 0.4-3.3), 3.6 (IQR: 1.3-Q3 not reached), and 1.1 (IQR: 0.3-3.6) years for group 1, their controls, group 2 and their controls, respectively. Overall 10-year mortality on KRT was higher among cancer patients vs. controls in group 1: 16% vs. 9% (aHR 2.02, 95% CI: 1.21-3.37) and in group 2: 23% vs. 14% (aHR 2.32, 95% CI: 1.11-4.85). In contrast, 10-year patient survival after first KT was comparable to controls (93% vs. 96%; 100% vs. 94%, in groups 1 and 2, respectively). In summary, childhood cancer survivors' KT was delayed, their overall mortality on KRT was increased, but once transplanted, their long-term outcome was similar to other KT recipients.< Réduire

Mots clés en anglais

Cancer

Children

Kidney Replacement Therapy

Kidney Transplantation

Malignancy

Mortality

URI

https://oskar-bordeaux.fr/handle/20.500.12278/203936

DOI

http://dx.doi.org/10.1016/j.ajt.2024.11.002

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Clinical outcomes of pediatric kidney replacement therapy after childhood cancer-An ESPN/ERA Registry study

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