BESSIERES, Benjamin; DUPUIS, Julien; GROC, Laurent; BONTEMPI, Bruno; NICOLE, Olivier

doi:10.1126/sciadv.ado1148

BESSIERES, Benjamin
Institut des Maladies Neurodégénératives [Bordeaux] [IMN]

DUPUIS, Julien

Interdisciplinary Institute for Neuroscience / Institut interdisciplinaire de neurosciences [Bordeaux] [IINS]

GROC, Laurent

Interdisciplinary Institute for Neuroscience / Institut interdisciplinaire de neurosciences [Bordeaux] [IINS]

Langue

Article de revue

Ce document a été publié dans

Science Advances. 2024-08-30, vol. 10, n° 35

Résumé en anglais

Initially hippocampal dependent, memory representations rely on a broadly distributed cortical network as they mature over time. How these cortical engrams acquire stability during systems-level memory consolidation without compromising their dynamic nature remains unclear. We identified a highly responsive "consolidation switch" in the synaptic composition of N-methyl-d-aspartate receptors (NMDARs), which dictates the progressive embedding and persistence of enduring memories in the rat cortex. Cortical GluN2B subunit-containing NMDARs were preferentially recruited upon encoding of associative olfactory memory to support neuronal allocation of memory engrams. As consolidation proceeds, a learning-induced redistribution of GluN2B subunit-containing NMDARs outward synapses increased synaptic GluN2A subunit contribution and enabled stabilization of remote memories. In contrast, synaptic reincorporation of GluN2B subunits occurred during subsequent forgetting. By manipulating the surface distribution of GluN2A and GluN2B subunit-containing NMDARs at cortical synapses, we uncovered that the rearrangement of GluN2B-containing NMDARs constitutes an essential tuning mechanism that determines the fate of cortical memory engrams and controls their malleability.< Réduire

Mots clés en anglais

Consolidation

Memory

Engram cells

NR2B NMDA receptor

Cerebral Cortex

URI

https://oskar-bordeaux.fr/handle/20.500.12278/203655

DOI

http://dx.doi.org/10.1126/sciadv.ado1148

Project ANR

Dynamiques des interactions hippocampo-corticales au cours de la formation des souvenirs récents et anciens: bases comportementales, cellulaires, moléculaires et fonctionnelles - ANR-14-CE13-0017
Rôle de l'organisation à l'échelle nanométrique des récepteurs NMDA dans le développement normal du cerveau et les troubles GRIN. - ANR-22-CE16-0026

Unités de recherche

Institut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287

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Synaptic rearrangement of NMDA receptors controls memory engram formation and malleability in the cortex