HOFFMANN DAHL, Elin; MBALA, Placide; JUCHET, Sylvain; TOURÉ, Abdoulaye; MONTOYO, Alice; SERRA, Beatrice; KOJAN, Richard; D'ORTENZIO, Eric; BLOMBERG, Bjorn; JASPARD, Marie

doi:10.1016/S2214-109X(24)00255-9

JUCHET, Sylvain
Bordeaux population health [BPH]
Global Health in the Global South [GHiGS]

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Ce document a été publié dans

The Lancet global health. 2024-10-01, vol. 12, n° 10, p. e1730-e1736

Résumé en anglais

Ebola virus disease kills more than half of people infected. Since the disease is transmitted via close human contact, identifying individuals at the highest risk of developing the disease is possible on the basis of the type of contact (correlated with viral exposure). Different candidates for post-exposure prophylaxis (PEP; ie, vaccines, antivirals, and monoclonal antibodies) each have their specific benefits and limitations, which we discuss in this Viewpoint. Approved monoclonal antibodies have been found to reduce mortality in people with Ebola virus disease. As monoclonal antibodies act swiftly by directly targeting the virus, they are promising candidates for targeted PEP in contacts at high risk of developing disease. This intervention could save lives, halt viral transmission, and, ultimately, help curtail outbreak propagation. We explore how a strategic integration of monoclonal antibodies and vaccines as PEP could provide both immediate and long-term protection against Ebola virus disease, highlighting ongoing clinical research that aims to refine this approach, and discuss the transformative potential of a successful PEP strategy to help control viral haemorrhagic fever outbreaks.< Réduire

Mots clés en anglais

Hemorrhagic Fever

Ebola

Humans

Post-Exposure Prophylaxis

Disease Outbreaks

Ebola Vaccines

Antibodies

Monoclonal

Antiviral Agents

Ebolavirus

URI

https://oskar-bordeaux.fr/handle/20.500.12278/203312

DOI

http://dx.doi.org/10.1016/S2214-109X(24)00255-9

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Improving Ebola virus disease outbreak control through targeted post-exposure prophylaxis

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Résumé en anglais

Mots clés en anglais

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DOI

Unités de recherche