BADAUT, Jerome; BLOCHET, Camille; OBENAUS, André; HIRT, Lorenz

doi:10.1016/j.tins.2024.06.003

Centre de résonance magnétique des systèmes biologiques [CRMSB]

BLOCHET, Camille

OBENAUS, André

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Trends in Neurosciences. 2024-08-01, vol. 47, n° 8, p. 651-664

Resumen en inglés

Caveolins are a family of transmembrane proteins located in caveolae, small lipid raft invaginations of the plasma membrane. The roles of caveolin-enriched lipid rafts are diverse, and include mechano-protection, lipid homeostasis, metabolism, transport, and cell signaling. Caveolin-1 (Cav-1) and other caveolins were described in endothelial cells and later in other cell types of the central nervous system (CNS), including neurons, astrocytes, oligodendrocytes, microglia, and pericytes. This pancellular presence of caveolins demands a better understanding of their functional roles in each cell type. In this review we describe the various functions of Cav-1 in the cells of normal and pathological brains. Several emerging preclinical findings suggest that Cav-1 could represent a potential therapeutic target in brain disorders.< Leer menos

Palabras clave en inglés

Blood–Brain Barrier

Caveolae

Lipid Rafts

Neuroinflammation

Neuronal Plasticity

Neurovascular Unit

URI

https://oskar-bordeaux.fr/handle/20.500.12278/203230

DOI

http://dx.doi.org/10.1016/j.tins.2024.06.003

Centros de investigación

Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536

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Physiological and pathological roles of caveolins in the central nervous system

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Centros de investigación