Cancer immunotherapy by γδ T cells

HAYDAY, Adrian; DECHANET-MERVILLE, Julie; ROSSJOHN, Jamie; SILVA-SANTOS, Bruno

doi:10.1126/science.abq7248

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

ROSSJOHN, Jamie

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Article de revue

Ce document a été publié dans

Science. 2024-10-04, vol. 386, n° 6717

Résumé en anglais

The premise of cancer immunotherapy is that cancers are specifically visible to an immune system tolerized to healthy self. The promise of cancer immunotherapy is that immune effector mechanisms and immunological memory can jointly eradicate cancers and inoperable metastases and de facto vaccinate against recurrence. For some patients with hitherto incurable diseases, including metastatic melanoma, this promise is being realized by game-changing immunotherapies based on αβ T cells. Today’s challenges are to bring benefit to greater numbers of patients of diverse ethnicities, target more cancer types, and achieve a cure while incurring fewer adverse events. In meeting those challenges, specific benefits may be offered by γδ T cells, which compose a second T cell lineage with distinct recognition capabilities and functional traits that bridge innate and adaptive immunity. γδ T cell–based clinical trials, including off-the-shelf adoptive cell therapy and agonist antibodies, are yielding promising results, although identifiable problems remain. In addressing those problems, we advocate that immunotherapies be guided by the distinctive biology of γδ T cells, as elucidated by ongoing research.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/202802

DOI

http://dx.doi.org/10.1126/science.abq7248

Unités de recherche

ImmunoConcEpT - UMR 5164

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