A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | LAPORTE, Damien | |
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | COURTOUT, Fabien | |
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | PINSON, Benoît | |
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | DOMPIERRE, Jim | |
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | SALIN, Bénédicte | |
| hal.structure.identifier | Biologie du fruit et pathologie [BFP] | |
| hal.structure.identifier | Institut National de la Recherche Agronomique [INRA] | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| dc.contributor.author | BROCARD, Lysiane | |
| hal.structure.identifier | Institut de biochimie et génétique cellulaires [IBGC] | |
| dc.contributor.author | SAGOT, Isabelle | |
| dc.date.accessioned | 2024-10-23T02:05:43Z | |
| dc.date.available | 2024-10-23T02:05:43Z | |
| dc.date.issued | 2015-07-06 | |
| dc.identifier.issn | 0021-9525 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/202681 | |
| dc.description.abstractEn | Cells perpetually face the decision to proliferate or to stay quiescent. Here we show that upon quiescence establishment, Schizosaccharomyces pombe cells drastically rearrange both their actin and microtubule (MT) cytoskeletons and lose their polarity. Indeed, while polarity markers are lost from cell extremities, actin patches and cables are reorganized into actin bodies, which are stable actin filament–containing structures. Astonishingly, MTs are also stabilized and rearranged into a novel antiparallel bundle associated with the spindle pole body, named Q-MT bundle. We have identified proteins involved in this process and propose a molecular model for Q-MT bundle formation. Finally and importantly, we reveal that Q-MT bundle elongation is involved in polarity reestablishment upon quiescence exit and thereby the efficient return to the proliferative state. Our work demonstrates that quiescent S. pombe cells assemble specific cytoskeleton structures that improve the swiftness of the transition back to proliferation. | |
| dc.language.iso | en | |
| dc.publisher | Rockefeller University Press | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/ | |
| dc.subject.en | benzimidazol-2-yl-carbamate | |
| dc.subject.en | MPA | |
| dc.subject.en | mycophenolic acid | |
| dc.subject.en | MT | |
| dc.subject.en | microtubule | |
| dc.subject.en | MTOC | |
| dc.subject.en | MT organizing center | |
| dc.subject.en | SPB | |
| dc.subject.en | benzimidazol-2-yl-carbamate MPA | |
| dc.subject.en | mycophenolic acid MT | |
| dc.subject.en | microtubule MTOC | |
| dc.subject.en | MT organizing center SPB | |
| dc.subject.en | spindle pole | |
| dc.title.en | A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1083/jcb.201502025 | |
| dc.subject.hal | Sciences du Vivant [q-bio] | |
| bordeaux.journal | Journal of Cell Biology | |
| bordeaux.page | 99-113 | |
| bordeaux.volume | 210 | |
| bordeaux.hal.laboratories | Biologie du Fruit & Pathologie (BFP) - UMR 1332 | * |
| bordeaux.issue | 1 | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | INRAE | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-04746272 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-04746272v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Cell%20Biology&rft.date=2015-07-06&rft.volume=210&rft.issue=1&rft.spage=99-113&rft.epage=99-113&rft.eissn=0021-9525&rft.issn=0021-9525&rft.au=LAPORTE,%20Damien&COURTOUT,%20Fabien&PINSON,%20Beno%C3%AEt&DOMPIERRE,%20Jim&SALIN,%20B%C3%A9n%C3%A9dicte&rft.genre=article |
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