BACINELLO, Daniel; GARANGER, Elisabeth; TATON, Daniel; TAM, Kam Chiu; LECOMMANDOUX, Sebastien

doi:10.1016/j.eurpolymj.2014.09.001

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BACINELLO, Daniel
Laboratoire de Chimie des Polymères Organiques [LCPO]
Institute for Nanotechnology [Waterloo]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

GARANGER, Elisabeth

Laboratoire de Chimie des Polymères Organiques [LCPO]
Institut Européen de Chimie et Biologie [IECB]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

TATON, Daniel

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering

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European Polymer Journal. 2015, vol. 62, p. 363-373

Elsevier

Resumen en inglés

The synthetic semi-crystalline polymer poly(trimethylene carbonate) PTMC50 was linked to the synthetic poly(amino acid) poly(glutamic acid) (PGA(15)) using the peptide PVGLIG, known to be selectively cleaved by the tumor-associated enzyme matrix metalloproteinase 2 (MMP-2), by a combination of thiol-ene coupling and ring-opening polymerization. Stable, monodisperse, sub-micron sized polymersomes were subsequently obtained by self-assembly and characterized by dynamic and static light scattering (DLS and SLS) and transmission electron microscopy (TEM). These vesicles showed selective degradation in the presence of MMP-2 as probed by DLS. The model drug imipramine hydrochloride was loaded at 35% encapsulation efficiency by co-precipitation and displayed controlled drug-release behavior. Drug release rates showed several fold increases when exposed to pH, temperature and most significantly, to the tumor-associated enzyme MMP-2. Such structures, bearing precise location of the cleavable peptide sequence, may hold promise as future specific and controlled drug-delivery systems. (C) 2014 Elsevier Ltd. All rights reserved.< Leer menos

Palabras clave en inglés

BLOCK-COPOLYMERS

Polymersome

NANOCARRIERS

DELIVERY

MICELLES

Matrix metalloproteinase

Drug delivery systems

Poly(trimethylene carbonate)

Thiol-ene

Cancer targeting

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Tailored drug-release from multi-functional polymer-peptide hybrid vesicles

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