Synthesis, self-assembly, and degradation of amphiphilic triblock copolymers with fully photodegradable hydrophobic blocks
BONDUELLE, Colin
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Voir plus >
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
BONDUELLE, Colin
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Réduire
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Langue
en
Article de revue
Ce document a été publié dans
Canadian Journal of Chemistry. 2015, vol. 93, n° 1, p. 126-133
NRC Research Press
Résumé en anglais
The development of stimuli-responsive materials is of significant interest for many applications including drug delivery, medical imaging, sensors, and microfluidic devices. Among the available stimuli, light is particularly ...Lire la suite >
The development of stimuli-responsive materials is of significant interest for many applications including drug delivery, medical imaging, sensors, and microfluidic devices. Among the available stimuli, light is particularly attractive as it can be applied with high spatial and temporal resolution. We describe here the synthesis of amphiphilic triblock copolymers composed of poly(ethylene glycol) and a hydrophobic block containing o-nitrobenzyl esters throughout the backbone using copper-catalyzed azide-alkyne cycloaddition chemistry. These materials were designed to have a high weight fraction of the hydrophobic block to favour nonmicellar aggregates. The self-assembly in water was studied using nanoprecipitation and the resulting assemblies were characterized by dynamic light scattering and transmission electron microscopy. Under optimized conditions, it was possible to prepare polymer vesicles, commonly referred to as polymersomes, with diameters of approximately 100 nm. The degradation of these materials in response to UV light was studied by spectroscopy, light scattering, and electron microscopy, demonstrating that the vesicles were broken down. These results suggest the potential of these materials for applications such as encapsulation and release.< Réduire
Mots clés en anglais
TRIGGERED RELEASE
DRUG-DELIVERY
DESIGN
photodegradable
stimuli responsive
vesicles
polymersomes
self-assembly
NANOPOROUS THIN-FILMS
DIBLOCK COPOLYMERS
CLICK POLYMERIZATION
RESPONSIVE POLYMERS
NANOPARTICLES
HYDROGELS
MICELLES
Origine
Importé de halUnités de recherche