WESKAMM, Leonie M; TARNOW, Paulina; HARMS, Charlotte; HUCHON, Melanie; RAADSEN, Matthijs P; FRIEDRICH, Monika; RUBENACKER, Laura; GRUTTNER, Cordula; GARCIA, Mariana G; KOCH, Till; BECKER, Stephan; SUTTER, Gerd; LHOMME, Edouard; HAAGMANS, Bart L; FATHI, Anahita; BLOIS, Sandra M; DAHLKE, Christine; RICHERT, Laura; ADDO, Marylyn M

doi:10.1016/j.isci.2024.110470

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iScience. 2024-08-16, vol. 27, n° 8, p. 110470

Résumé en anglais

Besides neutralizing antibodies, which are considered an important measure for vaccine immunogenicity, Fc-mediated antibody functions can contribute to antibody-mediated protection. They are strongly influenced by structural antibody properties such as subclass and Fc glycan composition. We here applied a systems serology approach to dissect humoral immune responses induced by MVA-MERS-S, an MVA-vectored vaccine against the Middle East respiratory syndrome coronavirus (MERS-CoV). Building on preceding studies reporting the safety and immunogenicity of MVA-MERS-S, our study highlights the potential of a late boost, administered one year after prime, to enhance both neutralizing and Fc-mediated antibody functionality compared to the primary vaccination series. Distinct characteristics were observed for antibodies specific to the MERS-CoV spike protein S1 and S2 subunits, regarding subclass and glycan compositions as well as Fc functionality. These findings highlight the benefit of a late homologous booster vaccination with MVA-MERS-S and may be of interest for the design of future coronavirus vaccines.< Réduire

Mots clés en anglais

Cell biology

Immune response

Immunology

Virology

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https://oskar-bordeaux.fr/handle/20.500.12278/202529

DOI

http://dx.doi.org/10.1016/j.isci.2024.110470

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Dissecting humoral immune responses to an MVA-vectored MERS-CoV vaccine in humans using a systems serology approach

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