FAUQUIGNON, Martin; SOLBERG, Amalie; PORCAR, Lionel; CHAPEL, Jean-Paul; CHRISTENSEN, Bjørn E; SCHATZ, Christophe

doi:10.1021/acs.biomac.4c00717

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Centre de Recherche Paul Pascal [CRPP]

SOLBERG, Amalie
Norwegian University of Science and Technology [Trondheim] [NTNU]

PORCAR, Lionel
Institut Laue-Langevin [ILL]

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Article de revue

Ce document a été publié dans

Biomacromolecules. 2024-10-01, vol. 25, p. DOI: 10.1021/acs.biomac.4c00717

Résumé en anglais

Alginates are marine polysaccharides known for their ability to selectively bind calcium ions and form hydrogels. They are widely used in biomedical applications but are challenging to produce as nanogels. Here we introduce a self-assembly route to create stable alginate-based nanogels under near-equilibrium conditions. Guluronate (G) blocks, which interact with divalent cations such as Ca, Ba, and Sr, were extracted from alginates and covalently linked through their reducing end to the reducing end of dextran (Dex) chains, forming linear block copolymers that self-assemble into micellar nanogels with a core-corona structure in the presence of these ions. Real-time dynamic light scattering (DLS) and small-angle neutron scattering (SANS) were used to study the self-assembly mechanism of the copolymer during dialysis against divalent ions. For the G--Dex copolymer, we achieved spherical micelles with an 8 nm radius and an aggregation number of around 20. Although the type of divalent cation affected micelle stability, it did not influence their size. Micellar nanogels are dynamic structures, capable of ion exchange, and can disassemble with chelating agents like ethylenediamine tetraacetic acid (EDTA).< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/202268

DOI

http://dx.doi.org/10.1021/acs.biomac.4c00717

Lien vers les données de la recherche

https://doi.ill.fr/10.5291/ILL-DATA.9-11-2032

Project ANR

Auto-Assemblage de bicouches de copolymères amphiphiles induit par une surface - ANR-18-CE06-0016

Unités de recherche

Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629

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Micellar Nanogels from Alginate-Based Diblock Copolysaccharides