BACINELLO, Daniel; GARANGER, Elisabeth; TATON, Daniel; TAM, Kam Chiu; LECOMMANDOUX, Sebastien

doi:10.1021/bm500296n

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BACINELLO, Daniel
Laboratoire de Chimie des Polymères Organiques [LCPO]
Institute for Nanotechnology [Waterloo]

GARANGER, Elisabeth

Laboratoire de Chimie des Polymères Organiques [LCPO]
Imagerie Moléculaire et Nanobiotechnologies - Institut Européen de Chimie et Biologie [IECB]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences

TATON, Daniel

Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering

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Biomacromolecules. 2014, vol. 15, n° 5, p. 1882-1888

American Chemical Society

Résumé en anglais

The peptide PVGLIG, which is known to be selectively cleaved by the tumor-associated enzyme matrix metalloproteinase-2 (MMP-2), was conjugated to a-alkene poly(trimethylene carbonate) (PTMC) blocks of varying sizes via UV-initiated thiol-ene "click" chemistry. The PTMC precursor was synthesized by metal-free ring-opening polymerization using ally! alcohol as an initiator and an N-heterocyclic carbene as an organic catalyst. The unprecedented PVGLIG-b-PTMC hybrids were self-assembled in aqueous solution and various submicrometer-sized morphologies obtained by a nanoprecipitation process. Characterization of particle morphology was carried out by multiangle dynamic light scattering (DLS) and static light scattering (SLS) evidencing spherical nanoparticles with different morphologies and narrow size distributions. Microstructure details were also observed on transmission electron micrographs and were in good agreement with light scattering measurements showing the assembly of core shell, large compound micelles, and vesicle morphologies, the particle morphology varying with the hydrophilic weight fractions (f) of the hybrids. These nanostructures displayed selective degradation in the presence of the cancer-associated enzyme MMP-2, as probed by the morphological change both by TEM and DLS. All these results demonstrated that PVGLIG-b-PTMC hybrids were suitable to target the tumor microenvironment.< Réduire

Mots clés en anglais

RING-OPENING POLYMERIZATION

BLOCK-COPOLYMERS

DRUG-DELIVERY

MICELLES

NANOPARTICLES

CHIMERAS

CARRIERS

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Enzyme-Degradable Self-Assembled Nanostructures from Polymer-Peptide Hybrids

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