Multivalent effect of glycopolypeptide based nanoparticles for galectin binding
BONDUELLE, Colin
Laboratoire de Chimie des Polymères Organiques [LCPO]
Laboratoire de chimie de coordination [LCC]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Laboratoire de chimie de coordination [LCC]
DE OLIVEIRA, Hugo
Laboratoire de Chimie des Polymères Organiques [LCPO]
INSERM, U1026, Tissue Bioengn, Univ Bordeaux
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Laboratoire de Chimie des Polymères Organiques [LCPO]
INSERM, U1026, Tissue Bioengn, Univ Bordeaux
BONDUELLE, Colin
Laboratoire de Chimie des Polymères Organiques [LCPO]
Laboratoire de chimie de coordination [LCC]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Laboratoire de chimie de coordination [LCC]
DE OLIVEIRA, Hugo
Laboratoire de Chimie des Polymères Organiques [LCPO]
INSERM, U1026, Tissue Bioengn, Univ Bordeaux
Laboratoire de Chimie des Polymères Organiques [LCPO]
INSERM, U1026, Tissue Bioengn, Univ Bordeaux
HEISE, Andreas
Dublin City Univ, Sci Chem Sci
Pol Chem & Biomat Lab, Dept Pharmaceut & Med Chem, Dublin
Dublin City Univ, Sci Chem Sci
Pol Chem & Biomat Lab, Dept Pharmaceut & Med Chem, Dublin
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
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Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Langue
en
Article de revue
Ce document a été publié dans
Chemical Communications. 2016, vol. 52, n° 75, p. 11251-11254
Royal Society of Chemistry
Résumé en anglais
Synthetic glycopolypeptides are versatile glycopolymers used to conceive bioinspired nanoassemblies. In this work, novel amphiphilic glycopolypeptides were designed to incorporate lactose or galactan in order to prepare ...Lire la suite >
Synthetic glycopolypeptides are versatile glycopolymers used to conceive bioinspired nanoassemblies. In this work, novel amphiphilic glycopolypeptides were designed to incorporate lactose or galactan in order to prepare polymeric nanoassemblies with sizes below 50 nm. The bioactivity of the two different outer surface sugar units was evaluated by defining glycan relative binding affinities to human galectins 1 and 3. A specific multivalent effect was found only for polymeric nanoparticles displaying galactan with a significant increase of the binding activity as compared to free glycan in solution. Such synthetic designs present great potential as therapeutic tools to address galectin related pathologies.< Réduire
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