BONIFACE, Katia

doi:10.5826/dpc.1304S2a314S

Biothérapies des maladies génétiques et cancers
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

Langue

Article de revue

Ce document a été publié dans

Dermatology Practical and Conceptual. 2023, vol. 13

Résumé en anglais

Vitiligo is a chronic auto-immune disease characterized by skin depigmentation due to the loss of melanocytes. The better understanding of the disease mechanisms is currently undergoing a significant dynamism, opening a new era in therapeutic development. The pathophysiology of vitiligo has attracted the attention of researchers for years and many advances have been made in clarifying the crosstalk between the cellular players involved in the development of vitiligo lesions. The understanding of the complex interactions between epidermal cells (i.e. melanocytes and keratinocytes), dermal fibroblasts, and immune cells, led to a better characterization of the signals leading to the loss of melanocytes. Recent advances highlighted the role resident T memory cells in the development and recurrence of lesions. This narrative review aims to give an overview of the mechanisms leading to melanocyte disappearance in vitiligo, with a focus on the intercellular interaction network involved in the activation of the local skin immune response< Réduire

Mots clés en anglais

Vitiligo

Melanocytes

Keratinocytes

Fibroblasts

Immune cells

Resident memory T cells

Cytokines

URI

https://oskar-bordeaux.fr/handle/20.500.12278/201842

DOI

http://dx.doi.org/10.5826/dpc.1304S2a314S

Unités de recherche

ImmunoConcEpT - UMR 5164

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Aetiopathogenesis of Vitiligo

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Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche