BESTARD, O.; KAMINSKI, Hannah; COUZI, Lionel; FERNÁNDEZ-RUIZ, M.; MANUEL, O.

doi:10.3389/ti.2023.11963

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

COUZI, Lionel
Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

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Article de revue

Ce document a été publié dans

Transplant International. 2023, vol. 36

Résumé en anglais

Utilizing assays that assess specific T-cell-mediated immunity against cytomegalovirus (CMV) holds the potential to enhance personalized strategies aimed at preventing and treating CMV in organ transplantation. This includes improved risk stratification during transplantation compared to relying solely on CMV serostatus, as well as determining the optimal duration of antiviral prophylaxis, deciding on antiviral therapy when asymptomatic replication occurs, and estimating the risk of recurrence. In this review, we initially provide an overlook of the current concepts into the immune control of CMV after transplantation. We then summarize the existent literature on the clinical experience of the use of immune monitoring in organ transplantation, with a particular interest on the outcomes of interventional trials. Current evidence indicates that cell-mediated immune assays are helpful in identifying patients at low risk for replication for whom preventive measures against CMV can be safely withheld. As more data accumulates from these and other clinical scenarios, it is foreseeable that these assays will likely become part of the routine clinical practice in organ transplantation.< Réduire

Mots clés en anglais

Immune monitoring

Cytomegalovirus management

Innate immunity

Preventive strategies

Antiviral prophylaxis

URI

https://oskar-bordeaux.fr/handle/20.500.12278/201838

DOI

http://dx.doi.org/10.3389/ti.2023.11963

Unités de recherche

ImmunoConcEpT - UMR 5164

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Cytomegalovirus Cell-Mediated Immunity: Ready for Routine Use?

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Résumé en anglais

Mots clés en anglais

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DOI

Unités de recherche