VAN DER HEIDE, Frank C T; KHAWAJA, Anthony; BERENDSCHOT, Tos T J M; LITTLEJOHNS, Thomas J; KUŹMA, Elżbieta; LUBEN, Robert; PATEL, Praveen J; FOSTER, Paul J; BERTELSEN, Geir; VON HANNO, Therese; JOHNSEN, Bente; SCHIRMER, Henrik; REBOUÇAS, Sara C L; GRASSET, Leslie; DELCOURT, Cecile; HELMER, Catherine; STEHOUWER, Coen D A

doi:10.1002/alz.13167

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Article de revue

Ce document a été publié dans

Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2024-01-01, vol. 20, n° 1, p. 211-220

Résumé en anglais

Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD). We performed an individual participant data meta-analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = 1087 cases of incident all-cause dementia; n = 520 cases incident AD; follow-up time median [interquartile range] 11.3 [8.8-11.5] years). General baseline characteristics of the study population were mean (standard deviation) age, 58.1 (8.8) years; 47% women. After adjustment, lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all-cause dementia and AD, respectively. Lower baseline macular ganglion cell-inner plexiform layer thickness was not significantly associated with these outcomes. These findings suggest that retinal neurodegeneration precedes the onset of clinical dementia. Retinal imaging tools may be informative biomarkers for the study of the early pathophysiology of dementia.< Réduire

Mots clés en anglais

Humans

Female

Middle Aged

Male

Prospective Studies

Tomography

Optical Coherence

Retina

Alzheimer Disease

Data Analysis

URI

https://oskar-bordeaux.fr/handle/20.500.12278/201694

DOI

http://dx.doi.org/10.1002/alz.13167

Project ANR

Histoire naturelle du déclin cognitif et du besoin de soins chez le sujet âgé
Dysfonctions vasculaires, cognitives et neurologiques du sujet âgé : l'influence de l'hyperhomocystéinémie sur la régulation épigénétique de gènes candidats

Unités de recherche

Bordeaux Population Health Research Center (BPH) - UMR 1219

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Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies