LESCOAT, Alain; BELLANDO-RANDONE, Silvia; CAMPOCHIARO, Corrado; DEL GALDO, Francesco; DENTON, Christopher P; FARRINGTON, Sue; GALETTI, Ilaria; KHANNA, Dinesh; KUWANA, Masataka; TRUCHETET, Marie-Elise; ALLANORE, Yannick; MATUCCI-CERINIC, Marco

doi:10.1016/S2665-9913(23)00212-6

Langue

Article de revue

Ce document a été publié dans

The Lancet Rheumatology. 2023, vol. 5, n° 11, p. e683-e694

Résumé en anglais

The identification of individuals with systemic sclerosis in an oligosymptomatic phase preceding the very early manifestations of the disease represents a challenge in the search for a new window of opportunity in systemic sclerosis. This phase could be identified in a clinical scenario as the pre-scleroderma phase, in which the disease would still be far from systemic sclerosis-related fibrotic or irreversible manifestations in skin or organs. In this Personal View, we discuss parameters and candidate definitions for a conceptual framework of pre-scleroderma, from the identification of populations at risk to autoantibodies and their potential functional activities. We discuss how this new paradigm of pre-scleroderma could represent a game-changing approach in the management of systemic sclerosis, allowing the treatment of patients at high risk of organ involvement or skin fibrosis before such events occur< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/201625

DOI

http://dx.doi.org/10.1016/S2665-9913(23)00212-6

Unités de recherche

ImmunoConcEpT - UMR 5164

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Beyond very early systemic sclerosis: deciphering pre‑scleroderma and its trajectories to open new avenues for preventive medicine

Langue

Ce document a été publié dans

Résumé en anglais

URI

DOI

Unités de recherche