NEQAL, Mehdi; PICHAVANT, Loïc; GAUTHIER, Mario; HÉROGUEZ, Valérie

doi:10.1016/j.colsurfa.2016.04.056

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NEQAL, Mehdi
Laboratoire de Chimie des Polymères Organiques [LCPO]
Department of Chemistry [Waterloo]

PICHAVANT, Loïc
Laboratoire de Chimie des Polymères Organiques [LCPO]

GAUTHIER, Mario
Department of Chemistry [Waterloo]

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Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2016, vol. 510, n° si, p. 254-262

Elsevier

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Dispersion Ring-Opening Metathesis Polymerization (ROMP) of norbornene (Nb) in the presence of a hydrophilic alpha-norbornenyl-polyglycidol macromonomer is a powerful method to obtain stabilized polymeric core-shell nanoparticles (NPs). Thanks to their high hydroxyl functionality content, one for every structural unit along the chain, the polyglycidol-based NPs can be viewed as plurifunctional platforms for the attachment of active molecules. The synthesis of polyglycidol macromonomers by anionic polymerization and their copolymerization with norbornene to give the NPs is described in the first part of this paper. In the second part, we take advantage of the presence of the hydroxyl groups to synthesize NPs with a high functionalization capacity. Dodecylamine, a primary amine known for its biocidal properties was selected as a model molecule and conjugated to the polyglycidol chains using a pH-sensitive imine bond. (C) 2016 Elsevier B.V. All rights reserved.< Leer menos

Palabras clave en inglés

Functionalized nanoparticles

ROMP

Dispersion polymerization

Macromonomers

Polyglycidol

Dodecylamine

CONJUGATE NANOPARTICLES

POLY(ETHYLENE OXIDE)

BLOCK-COPOLYMERS

DELIVERY

POLYMERS

GLYCIDOL

SHELL

CORE

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Plurifunctional polyglycidol-based particles prepared by Dispersion Ring-Opening Metathesis Polymerization

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