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Aging, sex, metabolic and life experience factors: Contributions to neuro-inflammaging in Alzheimer’s disease research

dc.rights.licenseopenen_US
dc.contributor.authorSINGHAARACHCHI, Pasindu Hansana
dc.contributor.authorANTAL, Peter
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCALON, Frederic
dc.contributor.authorCULMSEE, Carsten
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDELPECH, Jean-Christophe
dc.contributor.authorFELDOTTO, Martin
dc.contributor.authorGEERTSEMA, Jorine
dc.contributor.authorHOEKSEMA, Emmy E.
dc.contributor.authorKOROSI, Aniko
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
dc.contributor.authorMCQUALTER, Jonathan
dc.contributor.authorDE ROOIJ, Susanne R.
dc.contributor.authorRUMMEL, Christoph
dc.contributor.authorSLAYO, Mary
dc.contributor.authorSOMINSKY, Luba
dc.contributor.authorSPENCER, Sarah J.
dc.date.accessioned2024-08-20T08:37:35Z
dc.date.available2024-08-20T08:37:35Z
dc.date.issued2024-07-01
dc.identifier.issn0149-7634en_US
dc.identifier.urioai:crossref.org:10.1016/j.neubiorev.2024.105724
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201190
dc.description.abstractEnAlzheimer’s disease (AD) is prevalent around the world, yet our understanding of the disease is still very limited. Recent work suggests that the cornerstone of AD may include the inflammation that accompanies it. Failure of a normal pro-inflammatory immune response to resolve may lead to persistent central inflammation that contributes to unsuccessful clearance of amyloid-beta plaques as they form, neuronal death, and ultimately cognitive decline. Individual metabolic, and dietary (lipid) profiles can differentially regulate this inflammatory process with aging, obesity, poor diet, early life stress and other inflammatory factors contributing to a greater risk of developing AD. Here, we integrate evidence for the interface between these factors, and how they contribute to a pro-inflammatory brain milieu. In particular, we discuss the importance of appropriate polyunsaturated fatty acids (PUFA) in the diet for the metabolism of specialised pro-resolving mediators (SPMs); raising the possibility for dietary strategies to improve AD outlook.
dc.description.sponsorshipRisk factors and markers for early detection of Alzheimer's Disease: focus on early-life adversity, inflammation and lipid mediatorsen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.sourcecrossref
dc.subject.enAdipokine
dc.subject.enEarly-life adversity
dc.subject.enInflammation Lipids
dc.subject.enMicroglia
dc.subject.enNutrition
dc.subject.enN-3 polyunsaturated fatty acids
dc.subject.enOxylipin
dc.subject.enSpecialized pro-resolving mediators
dc.subject.enSex
dc.title.enAging, sex, metabolic and life experience factors: Contributions to neuro-inflammaging in Alzheimer’s disease research
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neubiorev.2024.105724en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed38762130en_US
bordeaux.journalNeuroscience and Biobehavioral Reviewsen_US
bordeaux.page105724en_US
bordeaux.volume162en_US
bordeaux.hal.laboratoriesNutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04673371
hal.version1
hal.date.transferred2024-08-20T08:37:39Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuroscience%20and%20Biobehavioral%20Reviews&rft.date=2024-07-01&rft.volume=162&rft.spage=105724&rft.epage=105724&rft.eissn=0149-7634&rft.issn=0149-7634&rft.au=SINGHAARACHCHI,%20Pasindu%20Hansana&ANTAL,%20Peter&CALON,%20Frederic&CULMSEE,%20Carsten&DELPECH,%20Jean-Christophe&rft.genre=article


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